{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:46:43Z","timestamp":1791550003454,"version":"4.3.4"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"5","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007297","name":"DOD | United States Navy | ONR | Office of Naval Research Global","doi-asserted-by":"publisher","award":["ONR MURI N00014-16-1-2832"],"award-info":[{"award-number":["ONR MURI N00014-16-1-2832"]}],"id":[{"id":"10.13039\/100007297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R37MH087027"],"award-info":[{"award-number":["R37MH087027"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MIT Picower Innovation Fund"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,1,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The anatomy and dynamics of different layers of the cerebral cortex are distinct. Physiological work in the sensory cortex has investigated how different layers process sensory inputs, and how they are engaged during attention tasks. In the frontal and prefrontal cortices, where lamination is present, very few studies have investigated the role of distinct layers for cognition. We studied frontal cortex laminar neuronal activity as monkeys performed working memory tasks. Spiking and gamma-band activity (50\u2013150 Hz) in the superficial layers reflected active maintenance of working memories. Alpha\/beta frequencies (4\u201322 Hz) in the deep layers modulated the gamma activity in the superficial layers. This might serve a control function, allowing information to enter or exit active storage in superficial layers.<\/jats:p>","DOI":"10.1073\/pnas.1710323115","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T11:36:05Z","timestamp":1516102565000},"page":"1117-1122","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":312,"title":["Laminar recordings in frontal cortex suggest distinct layers for maintenance and control of working memory"],"prefix":"10.1073","volume":"115","author":[{"given":"Andr\u00e9 M.","family":"Bastos","sequence":"first","affiliation":[{"name":"The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;"},{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Loonis","sequence":"additional","affiliation":[{"name":"The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;"},{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kornblith","sequence":"additional","affiliation":[{"name":"The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;"},{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Lundqvist","sequence":"additional","affiliation":[{"name":"The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;"},{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl K.","family":"Miller","sequence":"additional","affiliation":[{"name":"The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;"},{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13473"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.63.6.1385"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504172112"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5580-10.2011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011284108"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402773111"},{"key":"e_1_3_3_7_2","first-page":"31","article-title":"Distinct superficial and deep laminar domains of activity in the visual cortex during rest and stimulation","volume":"4","author":"Maier A","year":"2010","unstructured":"A Maier, GK Adams, C Aura, DA Leopold, Distinct superficial and deep laminar domains of activity in the visual cortex during rest and stimulation. Front Syst Neurosci 4, 31 (2010).","journal-title":"Front Syst Neurosci"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00846.2012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.10.020"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5127-13.2014"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00624.2014"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-16-05154.1996"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab0551"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.028"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00106.2010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.038"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018733"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00029"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.09.020"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1798"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138071"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.029"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00186"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117190108"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128115"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00263.2005"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08573"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00011"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601335"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902770204"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00994.2003"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.038"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.018"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.018"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.03.003"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23458"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1710323115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1710323115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:51:03Z","timestamp":1649818263000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1710323115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,1,30]]}},"alternative-id":["10.1073\/pnas.1710323115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1710323115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]},"assertion":[{"value":"2018-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}