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In this study, combining the analysis of EC-\/pericyte-specific\n                    <jats:italic>Cd146<\/jats:italic>\n                    -KO mice and in vitro BBB models, we report CD146 as a dynamic coordinator regulating the communication between ECs and pericytes within the neurovascular unit during BBB development. Our study demonstrates that a single cell-adhesion receptor, CD146, acts as an essential regulator to coordinate pericyte\u2013EC communication and BBB formation during embryogenesis. Furthermore, it identifies CD146 as a potential key therapeutic target for neurological diseases related to cerebrovascular disorders.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1710848114","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T20:40:20Z","timestamp":1503348020000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":196,"title":["CD146 coordinates brain endothelial cell\u2013pericyte communication for blood\u2013brain barrier development"],"prefix":"10.1073","volume":"114","author":[{"given":"Jianan","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, 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