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Our findings suggest that lowering brain levels of urea and\/or ammonia would be a worthwhile therapeutic target in HD.<\/jats:p>","DOI":"10.1073\/pnas.1711243115","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T15:07:46Z","timestamp":1513004866000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":105,"title":["Brain urea increase is an early Huntington\u2019s disease pathogenic event observed in a prodromal transgenic sheep model and HD cases"],"prefix":"10.1073","volume":"114","author":[{"given":"Renee R.","family":"Handley","sequence":"first","affiliation":[{"name":"Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J.","family":"Reid","sequence":"additional","affiliation":[{"name":"Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudiger","family":"Brauning","sequence":"additional","affiliation":[{"name":"Invermay Agricultural Centre, AgResearch Ltd., Mosgiel 9053, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maclean","sequence":"additional","affiliation":[{"name":"Invermay Agricultural Centre, AgResearch Ltd., Mosgiel 9053, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Mears","sequence":"additional","affiliation":[{"name":"Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imche","family":"Fourie","sequence":"additional","affiliation":[{"name":"Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Patassini","sequence":"additional","affiliation":[{"name":"Centre for Brain Research, Faculty of Medical and Health Science, The University of Auckland, Auckland 1023, New Zealand;"},{"name":"Centre for Advanced Discovery and Experimental Therapeutics, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth J. 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