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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,2,27]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Immunopathology after\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    infection is the major cause of human suffering associated with this pathogen, yet the immune responses that drive pathology are not well defined. We demonstrate that a mucosal influx of neutrophils and CXCR3-driven CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells is required for\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    pathology and does not contribute to bacterial clearance. Our study decouples immune-mediated pathology from immune-mediated protection for\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    , which will have important translational implications for the development of vaccines and CXCR3-mediated treatments.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1711356115","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T15:05:18Z","timestamp":1518188718000},"page":"2216-2221","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["Pathology after\n                    <i>Chlamydia trachomatis<\/i>\n                    infection is driven by nonprotective immune cells that are distinct from protective populations"],"prefix":"10.1073","volume":"115","author":[{"given":"Rebeccah S.","family":"Lijek","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Helble","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Olive","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra W.","family":"Seiger","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Starnbach","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1412935"},{"key":"e_1_3_3_2_2","first-page":"799","article-title":"Characteristics of the Chlamydia trachomatis species\u2013Immunopathology and infections","volume":"21","author":"Choroszy-Kr\u00f3l IC","year":"2012","unstructured":"IC Choroszy-Kr\u00f3l, M Frej-M\u0105drzak, A Jama-Kmiecik, T Bober, J Jolanta Sarowska, Characteristics of the Chlamydia trachomatis species\u2013Immunopathology and infections. 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