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Our results identify a highly efficient immunosuppressive mechanism at play in the granuloma environment that aids in\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    persistence. The ability to modulate this pathway with safe and approved compounds could, however, facilitate chemotherapy-adjunctive host-directed therapy approaches for the control of TB.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1711373114","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T15:05:51Z","timestamp":1513609551000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":201,"title":["In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1073","volume":"115","author":[{"given":"Uma S.","family":"Gautam","sequence":"first","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor W.","family":"Foreman","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"},{"name":"Department of Microbiology &amp; Immunology, Tulane University School of Medicine, New Orleans, LA 70112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison N.","family":"Bucsan","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"},{"name":"Department of Microbiology &amp; Immunology, Tulane University School of Medicine, New Orleans, LA 70112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley V.","family":"Veatch","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toidi","family":"Adekambi","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia A.","family":"Golden","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee M.","family":"Gentry","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara A.","family":"Doyle-Meyers","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3719-0779","authenticated-orcid":false,"given":"Kasi E.","family":"Russell-Lodrigue","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Didier","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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