{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:01:17Z","timestamp":1783645277807,"version":"3.55.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,8,14]]},"abstract":"<jats:p>\n                    To identify molecular alterations implicated in the initiating\n steps of breast tumorogenesis, we compared the gene expression profiles\n of normal and ductal carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    (DCIS) mammary\n epithelial cells by using serial analysis of gene expression (SAGE).\n Through the pair-wise comparison of normal and DCIS SAGE libraries, we\n identified several differentially expressed genes. Here, we report the\n characterization of one of these genes, HIN-1 (high in normal-1). HIN-1\n expression is significantly down regulated in 94% of human breast\n carcinomas and in 95% of preinvasive lesions, such as ductal and\n lobular carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    . This decrease in HIN-1\n expression is accompanied by hypermethylation of its promoter in the\n majority of breast cancer cell lines (&gt;90%) and primary tumors\n (74%). HIN-1 is a putative cytokine with no significant homology to\n known proteins. Reintroduction of HIN-1 into breast cancer cells\n inhibits cell growth. These results indicate that HIN-1 is a candidate\n tumor suppressor gene that is inactivated at high frequency in the\n earliest stages of breast tumorogenesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.171138398","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:34:10Z","timestamp":1027679650000},"page":"9796-9801","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":105,"title":["HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells"],"prefix":"10.1073","volume":"98","author":[{"given":"Ian E.","family":"Krop","sequence":"first","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Sgroi","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale A.","family":"Porter","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Lunetta","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebbecca","family":"LeVangie","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Seth","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Kaelin","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rhei","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Bosenberg","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Schnitt","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Marks","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zrinka","family":"Pagon","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drazen","family":"Belina","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasminka","family":"Razumovic","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelia","family":"Polyak","sequence":"additional","affiliation":[{"name":"Departments of Adult Oncology and\r Biostatistics, Dana\u2013Farber Cancer Institute, Boston, MA\r 02115; Departments of Surgery and Pathology,\r Brigham and Women's Hospital, Boston, MA 02115;\r Department of Pathology, Beth-Israel Deaconess Medical\r Center, Boston, MA 02115; Department of Medicine,\r Children's Hospital, Boston, MA 02115; Department of\r Pathology, Massachusetts General Hospital, Charlestown, MA 02129;\r Department of Medicine, Harvard Medical School, Boston, MA\r 02115; Harvard School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,7,31]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s001090050128","volume":"75","author":"Beckmann M W","year":"1997","unstructured":"M W Beckmann, D Niederacher, H G Schnurch, B A Gusterson, H G Bender J Mol Med 75, 429\u2013439 (1997).","journal-title":"J Mol Med"},{"key":"e_1_3_4_2_2","volume-title":"Ductal Carcinoma In Situ of the Breast","author":"Silverstein M J","year":"1997","unstructured":"M J Silverstein Ductal Carcinoma In Situ of the Breast (Williams & Wilkins, Baltimore, 1997)."},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.270.5235.484","volume":"270","author":"Velculescu V E","year":"1995","unstructured":"V E Velculescu, L Zhang, B Vogelstein, K W Kinzler Science 270, 484\u2013487 (1995).","journal-title":"Science"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1126\/science.289.5482.1197","volume":"289","author":"St Croix B","year":"2000","unstructured":"B St Croix, C Rago, V Velculescu, G Traverso, K E Romans, E Montgomery, A Lal, G J Riggins, C Lengauer, B Vogelstein, K W Kinzler Science 289, 1197\u20131202 (2000).","journal-title":"Science"},{"key":"e_1_3_4_5_2","first-page":"5656","volume":"59","author":"Sgroi D C","year":"1999","unstructured":"D C Sgroi, S Teng, G Robinson, R LeVangie, J R Hudson, A G Elkahloun Cancer Res 59, 5656\u20135661 (1999).","journal-title":"Cancer Res"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/38525","volume":"389","author":"Polyak K","year":"1997","unstructured":"K Polyak, Y Xia, J L Zweier, K W Kinzler, B Vogelstein Nature (London) 389, 300\u2013305 (1997).","journal-title":"Nature (London)"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.1073\/pnas.95.12.6870","volume":"95","author":"Herman J G","year":"1998","unstructured":"J G Herman, A Umar, K Polyak, J R Graff, N Ahuja, J P Issa, S Markowitz, J K Willson, S R Hamilton, K W Kinzler, et al. Proc Natl Acad Sci USA 95, 6870\u20136875 (1998).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng0796-343","volume":"13","author":"Thiagalingam S","year":"1996","unstructured":"S Thiagalingam, C Lengauer, F S Leach, M Schutte, S A Hahn, J Overhauser, J K Willson, S Markowitz, S R Hamilton, S E Kern, et al. Nat Genet 13, 343\u2013346 (1996).","journal-title":"Nat Genet"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","volume":"95","author":"He T C","year":"1998","unstructured":"T C He, S Zhou, L T da Costa, J Yu, K W Kinzler, B Vogelstein Proc Natl Acad Sci USA 95, 2509\u20132514 (1998).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/70487","volume":"23","author":"Velculescu V E","year":"1999","unstructured":"V E Velculescu, S L Madden, L Zhang, A E Lash, J Yu, C Rago, A Lal, C J Wang, G A Beaudry, K M Ciriello, et al. Nat Genet 23, 387\u2013388 (1999).","journal-title":"Nat Genet"},{"key":"e_1_3_4_11_2","first-page":"5403","volume":"59","author":"Lal A","year":"1999","unstructured":"A Lal, A E Lash, S F Altschul, V Velculescu, L Zhang, R E McLendon, M A Marra, C Prange, P J Morin, K Polyak, et al. Cancer Res 59, 5403\u20135407 (1999).","journal-title":"Cancer Res"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.physiol.62.1.595","volume":"62","author":"Pohl M","year":"2000","unstructured":"M Pohl, R O Stuart, H Sakurai, S K Nigam Annu Rev Physiol 62, 595\u2013620 (2000).","journal-title":"Annu Rev Physiol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0925-4773(99)00325-1","volume":"92","author":"Warburton D","year":"2000","unstructured":"D Warburton, M Schwarz, D Tefft, G Flores-Delgado, K D Anderson, W V Cardoso Mech Dev 92, 55\u201381 (2000).","journal-title":"Mech Dev"},{"key":"e_1_3_4_14_2","first-page":"220","volume":"55","author":"Fong K M","year":"1995","unstructured":"K M Fong, P V Zimmerman, P J Smith Cancer Res 55, 220\u2013223 (1995).","journal-title":"Cancer Res"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<219::AID-IJC9>3.0.CO;2-3","volume":"81","author":"Saric T","year":"1999","unstructured":"T Saric, Z Brkanac, D A Troyer, S S Padalecki, M Sarosdy, K Williams, L Abadesco, R J Leach, P O'Connell Int J Cancer 81, 219\u2013224 (1999).","journal-title":"Int J Cancer"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0002-9440(10)65083-3","volume":"156","author":"Yamano M","year":"2000","unstructured":"M Yamano, H Fujii, T Takagaki, N Kadowaki, H Watanabe, T Shirai Am J Pathol 156, 2123\u20132133 (2000).","journal-title":"Am J Pathol"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0046-8177(96)90449-9","volume":"27","author":"Yamamoto Y","year":"1996","unstructured":"Y Yamamoto, Y Kishimoto, A K Virmani, A Smith, F Vuitch, J Albores-Saavedra, A F Gazdar Hum Pathol 27, 782\u2013786 (1996).","journal-title":"Hum Pathol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0168-9525(99)01971-X","volume":"16","author":"Baylin S B","year":"2000","unstructured":"S B Baylin, J G Herman Trends Genet 16, 168\u2013174 (2000).","journal-title":"Trends Genet"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.89.5.1827","volume":"89","author":"Frommer M","year":"1992","unstructured":"M Frommer, L E McDonald, D S Millar, C M Collis, F Watt, G W Grigg, P L Molloy, C L Paul Proc Natl Acad Sci USA 89, 1827\u20131831 (1992).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","volume":"93","author":"Herman J G","year":"1996","unstructured":"J G Herman, J R Graff, S Myohanen, B D Nelkin, S B Baylin Proc Natl Acad Sci USA 93, 9821\u20139826 (1996).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_21_2","first-page":"169","volume":"11","author":"Russo J","year":"1999","unstructured":"J Russo, I H Russo Oncol Res 11, 169\u2013178 (1999).","journal-title":"Oncol Res"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1002\/1097-0142(20000601)88:11<2553::AID-CNCR18>3.0.CO;2-V","volume":"88","author":"Goldstein N S","year":"2000","unstructured":"N S Goldstein, F A Vicini, L L Kestin, M Thomas Cancer 88, 2553\u20132560 (2000).","journal-title":"Cancer"},{"key":"e_1_3_4_23_2","volume-title":"Mammary Development and Cancer","author":"Rudland P S","year":"1998","unstructured":"P S Rudland, D G Fernig, S Leinster, G G Lunt Mammary Development and Cancer (Portland Press, London, 1998)."},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1026487120779","volume":"5","author":"Howard B A","year":"2000","unstructured":"B A Howard, B A Gusterson J Mammary Gland Biol Neoplasia 5, 119\u2013137 (2000).","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"e_1_3_4_25_2","first-page":"5195","volume":"55","author":"Graff J R","year":"1995","unstructured":"J R Graff, J G Herman, R G Lapidus, H Chopra, R Xu, D F Jarrard, W B Isaacs, P M Pitha, N E Davidson, S B Baylin Cancer Res 55, 5195\u20135199 (1995).","journal-title":"Cancer Res"},{"key":"e_1_3_4_26_2","first-page":"4525","volume":"55","author":"Herman J G","year":"1995","unstructured":"J G Herman, A Merlo, L Mao, R G Lapidus, J P Issa, N E Davidson, D Sidransky, S B Baylin Cancer Res 55, 4525\u20134530 (1995).","journal-title":"Cancer Res"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jnci\/92.7.564","volume":"92","author":"Esteller M","year":"2000","unstructured":"M Esteller, J M Silva, G Dominguez, F Bonilla, X Matias-Guiu, E Lerma, E Bussaglia, J Prat, I C Harkes, E A Repasky, et al. J Natl Cancer Inst 92, 564\u2013569 (2000).","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_28_2","first-page":"4515","volume":"58","author":"Esteller M","year":"1998","unstructured":"M Esteller, P G Corn, J M Urena, E Gabrielson, S B Baylin, J G Herman Cancer Res 58, 4515\u20134518 (1998).","journal-title":"Cancer Res"},{"key":"e_1_3_4_29_2","first-page":"2552","volume":"54","author":"Ottaviano Y L","year":"1994","unstructured":"Y L Ottaviano, J P Issa, F F Parl, H S Smith, S B Baylin, N E Davidson Cancer Res 54, 2552\u20132555 (1994).","journal-title":"Cancer Res"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1128\/MCB.18.4.1793","volume":"18","author":"Foster S A","year":"1998","unstructured":"S A Foster, D J Wong, M T Barrett, D A Galloway Mol Cell Biol 18, 1793\u20131801 (1998).","journal-title":"Mol Cell Biol"},{"key":"e_1_3_4_31_2","first-page":"3508","volume":"58","author":"Huschtscha L I","year":"1998","unstructured":"L I Huschtscha, J R Noble, A A Neumann, E L Moy, P Barry, J R Melki, S J Clark, R R Reddel Cancer Res 58, 3508\u20133512 (1998).","journal-title":"Cancer Res"},{"key":"e_1_3_4_32_2","first-page":"4865","volume":"56","author":"Huynh H","year":"1996","unstructured":"H Huynh, L Alpert, M Pollak Cancer Res 56, 4865\u20134870 (1996).","journal-title":"Cancer Res"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/35016125","volume":"405","author":"Raman V","year":"2000","unstructured":"V Raman, S A Martensen, D Reisman, E Evron, W F Odenwald, E Jaffee, J Marks, S Sukumar Nature (London) 405, 974\u2013978 (2000).","journal-title":"Nature (London)"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1073\/pnas.100566997","volume":"97","author":"Ferguson A T","year":"2000","unstructured":"A T Ferguson, E Evron, C B Umbricht, T K Pandita, T A Chan, H Hermeking, J R Marks, A R Lambers, P A Futreal, M R Stampfer, S Sukumar Proc Natl Acad Sci USA 97, 6049\u20136054, . (First Published May 16, 2000; 10.1073\/pnas.100566997). (2000).","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.171138398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T01:17:35Z","timestamp":1654564655000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.171138398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,31]]},"references-count":34,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2001,8,14]]}},"alternative-id":["10.1073\/pnas.171138398"],"URL":"https:\/\/doi.org\/10.1073\/pnas.171138398","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,31]]},"assertion":[{"value":"2001-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}