{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:12:51Z","timestamp":1790838771467,"version":"4.1.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"51","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["GM083337"],"award-info":[{"award-number":["GM083337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["GM085354"],"award-info":[{"award-number":["GM085354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,12,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    We show that the temporal order of replication (replication timing, RT), normally an extremely stable cell type-specific chromosomal property, is altered in cells from two different premature aging (progeroid) diseases. By converting patient cells to stem cells and redifferentiating them as a model of disease progression, we identified the\n                    <jats:italic>TP63<\/jats:italic>\n                    gene as one of the earliest RT alterations and altered RT was associated with abnormal\n                    <jats:italic>TP63<\/jats:italic>\n                    gene expression.\n                    <jats:italic>TP63<\/jats:italic>\n                    mutations have been linked to other diseases that share clinical features of progeroid syndromes. These findings introduce an approach for disease marker discovery, identify molecular abnormalities distinguishing progeroid diseases from natural aging, and point to\n                    <jats:italic>TP63<\/jats:italic>\n                    as a molecular link to the pathophysiological manifestations of progeroid diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1711613114","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T15:15:14Z","timestamp":1512141314000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["DNA replication timing alterations identify common markers between distinct progeroid diseases"],"prefix":"10.1073","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-3875","authenticated-orcid":false,"given":"Juan Carlos","family":"Rivera-Mulia","sequence":"first","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Desprat","sequence":"additional","affiliation":[{"name":"Plateforme de Reprogrammation Cellulaire (SAFE-iPSC) Stem Cell Core Facility, Infrastructure Nationale d'Ing\u00e9nierie des Cellules Souches Pluripotentes et Cellules Diff\u00e9renci\u00e9es (INGESTEM), Centres Hospitaliers Universitaires de Montpellier, Hopital Saint Eloi, F3400 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Trevilla-Garcia","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cornacchia","sequence":"additional","affiliation":[{"name":"The Center for Stem Cell Biology, Memorial Sloan-Kettering Institute, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Schwerer","sequence":"additional","affiliation":[{"name":"Institute of Regenerative Medicine and Biotherapies, U1183 INSERM, Universit\u00e9 de Montpellier, F3400 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayo","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Sima","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Fells","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Studer","sequence":"additional","affiliation":[{"name":"The Center for Stem Cell Biology, Memorial Sloan-Kettering Institute, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Plateforme de Reprogrammation Cellulaire (SAFE-iPSC) Stem Cell Core Facility, Infrastructure Nationale d'Ing\u00e9nierie des Cellules Souches Pluripotentes et Cellules Diff\u00e9renci\u00e9es (INGESTEM), Centres Hospitaliers Universitaires de Montpellier, Hopital Saint Eloi, F3400 Montpellier, France;"},{"name":"Institute of Regenerative Medicine and Biotherapies, U1183 INSERM, Universit\u00e9 de Montpellier, F3400 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306;"},{"name":"Center for Genomics and Personalized Medicine, Florida State University, Tallahassee, FL 32306"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,12]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/35041705","article-title":"Lessons from human progeroid syndromes","volume":"408","author":"Martin GM","year":"2000","unstructured":"GM Martin, J Oshima, Lessons from human progeroid syndromes. Nature 408, 263\u2013266 (2000).","journal-title":"Nature"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1126\/science.1084125","article-title":"Lamin a truncation in Hutchinson-Gilford progeria","volume":"300","author":"De Sandre-Giovannoli A","year":"2003","unstructured":"A De Sandre-Giovannoli, , Lamin a truncation in Hutchinson-Gilford progeria. Science 300, 2055\u20132055 (2003).","journal-title":"Science"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature01629","article-title":"Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome","volume":"423","author":"Eriksson M","year":"2003","unstructured":"M Eriksson, , Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423, 293\u2013298 (2003).","journal-title":"Nature"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00418-016-1411-1","article-title":"Molecular insights into the premature aging disease progeria","volume":"145","author":"Vidak S","year":"2016","unstructured":"S Vidak, R Foisner, Molecular insights into the premature aging disease progeria. Histochem Cell Biol 145, 401\u2013417 (2016).","journal-title":"Histochem Cell Biol"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"8963","DOI":"10.1073\/pnas.0402943101","article-title":"Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome","volume":"101","author":"Goldman RD","year":"2004","unstructured":"RD Goldman, , Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 101, 8963\u20138968 (2004).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ceb.2015.05.007","article-title":"DNA repair defects and genome instability in Hutchinson-Gilford progeria syndrome","volume":"34","author":"Gonzalo S","year":"2015","unstructured":"S Gonzalo, R Kreienkamp, DNA repair defects and genome instability in Hutchinson-Gilford progeria syndrome. Curr Opin Cell Biol 34, 75\u201383 (2015).","journal-title":"Curr Opin Cell Biol"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2016.05.017","article-title":"Repression of the antioxidant NRF2 pathway in premature aging","volume":"165","author":"Kubben N","year":"2016","unstructured":"N Kubben, , Repression of the antioxidant NRF2 pathway in premature aging. Cell 165, 1361\u20131374 (2016).","journal-title":"Cell"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.arr.2016.06.002","article-title":"Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders","volume":"33","author":"Lu L","year":"2017","unstructured":"L Lu, W Jin, LL Wang, Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders. Ageing Res Rev 33, 30\u201335 (2017).","journal-title":"Ageing Res Rev"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/humu.23148","article-title":"Human RECQ helicase pathogenic variants, population variation and \u201cmissing\u201d diseases","volume":"38","author":"Fu W","year":"2017","unstructured":"W Fu, A Ligabue, KJ Rogers, JM Akey, Jr RJ Monnat, Human RECQ helicase pathogenic variants, population variation and \u201cmissing\u201d diseases. Hum Mutat 38, 193\u2013203 (2017).","journal-title":"Hum Mutat"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"e0167454","DOI":"10.1371\/journal.pone.0167454","article-title":"Loss of H3K9me3 correlates with ATM activation and histone H2AX phosphorylation deficiencies in Hutchinson-Gilford progeria syndrome","volume":"11","author":"Zhang H","year":"2016","unstructured":"H Zhang, , Loss of H3K9me3 correlates with ATM activation and histone H2AX phosphorylation deficiencies in Hutchinson-Gilford progeria syndrome. PLoS One 11, e0167454 (2016).","journal-title":"PLoS One"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1101\/gr.187989.114","article-title":"Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells","volume":"25","author":"Rivera-Mulia JC","year":"2015","unstructured":"JC Rivera-Mulia, , Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells. Genome Res 25, 1091\u20131103 (2015).","journal-title":"Genome Res"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ceb.2016.03.022","article-title":"Replication timing and transcriptional control: Beyond cause and effect-part III","volume":"40","author":"Rivera-Mulia JC","year":"2016","unstructured":"JC Rivera-Mulia, DM Gilbert, Replication timing and transcriptional control: Beyond cause and effect-part III. Curr Opin Cell Biol 40, 168\u2013178 (2016).","journal-title":"Curr Opin Cell Biol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nm1204","article-title":"Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome","volume":"11","author":"Scaffidi P","year":"2005","unstructured":"P Scaffidi, T Misteli, Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med 11, 440\u2013445 (2005).","journal-title":"Nat Med"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.1127168","article-title":"Lamin A-dependent nuclear defects in human aging","volume":"312","author":"Scaffidi P","year":"2006","unstructured":"P Scaffidi, T Misteli, Lamin A-dependent nuclear defects in human aging. Science 312, 1059\u20131063 (2006).","journal-title":"Science"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1083\/jcb.201306073","article-title":"Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence","volume":"203","author":"Swanson EC","year":"2013","unstructured":"EC Swanson, B Manning, H Zhang, JB Lawrence, Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence. J Cell Biol 203, 929\u2013942 (2013).","journal-title":"J Cell Biol"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.celrep.2014.12.055","article-title":"Global reorganization of the nuclear landscape in senescent cells","volume":"10","author":"Chandra T","year":"2015","unstructured":"T Chandra, , Global reorganization of the nuclear landscape in senescent cells. Cell Rep 10, 471\u2013483 (2015).","journal-title":"Cell Rep"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1101\/sqb.2015.80.027284","article-title":"Large-scale chromatin structure-function relationships during the cell cycle and development: Insights from replication timing","volume":"80","author":"Dileep V","year":"2015","unstructured":"V Dileep, JC Rivera-Mulia, J Sima, DM Gilbert, Large-scale chromatin structure-function relationships during the cell cycle and development: Insights from replication timing. Cold Spring Harb Symp Quant Biol 80, 53\u201363 (2015).","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1101\/gr.138032.112","article-title":"Correlated alterations in genome organization, histone methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome","volume":"23","author":"McCord RP","year":"2013","unstructured":"RP McCord, , Correlated alterations in genome organization, histone methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome. Genome Res 23, 260\u2013269 (2013).","journal-title":"Genome Res"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/cdd.2011.181","article-title":"Regulation of skin aging and heart development by TAp63","volume":"19","author":"Paris M","year":"2012","unstructured":"M Paris, M Rouleau, M Puc\u00e9at, D Aberdam, Regulation of skin aging and heart development by TAp63. Cell Death Differ 19, 186\u2013193 (2012).","journal-title":"Cell Death Differ"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/jid.2011.84","article-title":"p63, a story of mice and men","volume":"131","author":"Vanbokhoven H","year":"2011","unstructured":"H Vanbokhoven, G Melino, E Candi, W Declercq, p63, a story of mice and men. J Invest Dermatol 131, 1196\u20131207 (2011).","journal-title":"J Invest Dermatol"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"Human genomics. The genotype-tissue expression (GTEx) pilot analysis: Multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","unstructured":"; GTEx Consortium, Human genomics. The genotype-tissue expression (GTEx) pilot analysis: Multitissue gene regulation in humans. Science 348, 648\u2013660 (2015).","journal-title":"Science"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/mgg3.209","article-title":"Rothmund-Thomson syndrome: Novel pathogenic mutations and frequencies of variants in the RECQL4 and USB1 (C16orf57) gene","volume":"4","author":"Suter AA","year":"2016","unstructured":"AA Suter, , Rothmund-Thomson syndrome: Novel pathogenic mutations and frequencies of variants in the RECQL4 and USB1 (C16orf57) gene. Mol Genet Genomic Med 4, 359\u2013366 (2016).","journal-title":"Mol Genet Genomic Med"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09879","article-title":"Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome","volume":"472","author":"Liu G-H","year":"2011","unstructured":"G-H Liu, , Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature 472, 221\u2013225 (2011).","journal-title":"Nature"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.stem.2013.11.006","article-title":"Human iPSC-based modeling of late-onset disease via progerin-induced aging","volume":"13","author":"Miller JD","year":"2013","unstructured":"JD Miller, , Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell Stem Cell 13, 691\u2013705 (2013).","journal-title":"Cell Stem Cell"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/19531","article-title":"p63 is a p53 homologue required for limb and epidermal morphogenesis","volume":"398","author":"Mills AA","year":"1999","unstructured":"AA Mills, , p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708\u2013713 (1999).","journal-title":"Nature"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2009.04.003","article-title":"TAp63 prevents premature aging by promoting adult stem cell maintenance","volume":"5","author":"Su X","year":"2009","unstructured":"X Su, , TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5, 64\u201375 (2009).","journal-title":"Cell Stem Cell"},{"key":"e_1_3_4_27_2","first-page":"282","article-title":"The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells","volume":"142","author":"Suzuki D","year":"2015","unstructured":"D Suzuki, R Sahu, NA Leu, M Senoo, The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development 142, 282\u2013290 (2015).","journal-title":"Development"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/19539","article-title":"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development","volume":"398","author":"Yang A","year":"1999","unstructured":"A Yang, , p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398, 714\u2013718 (1999).","journal-title":"Nature"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/cdd.2010.59","article-title":"The p63 target HBP1 is required for skin differentiation and stratification","volume":"17","author":"Borrelli S","year":"2010","unstructured":"S Borrelli, , The p63 target HBP1 is required for skin differentiation and stratification. Cell Death Differ 17, 1896\u20131907 (2010).","journal-title":"Cell Death Differ"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.stem.2010.12.009","article-title":"\u0394Np63\u03b1 is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis","volume":"8","author":"Keyes WM","year":"2011","unstructured":"WM Keyes, , \u0394Np63\u03b1 is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell 8, 164\u2013176 (2011).","journal-title":"Cell Stem Cell"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1101\/gad.342305","article-title":"p63 deficiency activates a program of cellular senescence and leads to accelerated aging","volume":"19","author":"Keyes WM","year":"2005","unstructured":"WM Keyes, , p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 19, 1986\u20131999 (2005).","journal-title":"Genes Dev"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.molcel.2016.05.007","article-title":"Replicating large genomes: Divide and conquer","volume":"62","author":"Rivera-Mulia JC","year":"2016","unstructured":"JC Rivera-Mulia, DM Gilbert, Replicating large genomes: Divide and conquer. Mol Cell 62, 756\u2013765 (2016).","journal-title":"Mol Cell"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/jid.2008.12","article-title":"Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63","volume":"128","author":"Antonini D","year":"2008","unstructured":"D Antonini, , Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63. J Invest Dermatol 128, 1676\u20131685 (2008).","journal-title":"J Invest Dermatol"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1474-9728.2004.00105.x","article-title":"Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal\/mesenchymal defects and accelerated atherosclerosis","volume":"3","author":"Csoka AB","year":"2004","unstructured":"AB Csoka, , Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal\/mesenchymal defects and accelerated atherosclerosis. Aging Cell 3, 235\u2013243 (2004).","journal-title":"Aging Cell"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/ejhg.2008.270","article-title":"Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging","volume":"17","author":"Rodriguez S","year":"2009","unstructured":"S Rodriguez, F Copped\u00e8, H Sagelius, M Eriksson, Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging. Eur J Hum Genet 17, 928\u2013937 (2009).","journal-title":"Eur J Hum Genet"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/ncb1708","article-title":"Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing","volume":"10","author":"Scaffidi P","year":"2008","unstructured":"P Scaffidi, T Misteli, Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol 10, 452\u2013459 (2008).","journal-title":"Nat Cell Biol"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.stem.2010.12.002","article-title":"A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects","volume":"8","author":"Zhang J","year":"2011","unstructured":"J Zhang, , A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell 8, 31\u201345 (2011).","journal-title":"Cell Stem Cell"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"re9","DOI":"10.1126\/scisignal.aaa1033","article-title":"Maintaining epithelial stemness with p63","volume":"8","author":"Melino G","year":"2015","unstructured":"G Melino, EM Memmi, PG Pelicci, F Bernassola, Maintaining epithelial stemness with p63. Sci Signal 8, re9 (2015).","journal-title":"Sci Signal"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","unstructured":"X Su D Chakravarti ER Flores p63 steps into the limelight: Crucial roles in the suppression of tumorigenesis and metastasis. 13 136\u2013143 (2013).","DOI":"10.1038\/nrc3446"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/cdd.2009.25","article-title":"The alpha\/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins","volume":"16","author":"Wolff S","year":"2009","unstructured":"S Wolff, , The alpha\/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins. Cell Death Differ 16, 1108\u20131117 (2009).","journal-title":"Cell Death Differ"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4161\/cc.5.3.2415","article-title":"p63: A new link between senescence and aging","volume":"5","author":"Keyes WM","year":"2006","unstructured":"WM Keyes, AA Mills, p63: A new link between senescence and aging. Cell Cycle 5, 260\u2013265 (2006).","journal-title":"Cell Cycle"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1172\/JCI40267","article-title":"A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias","volume":"120","author":"Moretti F","year":"2010","unstructured":"F Moretti, , A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. J Clin Invest 120, 1570\u20131577 (2010).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/ncb1988","article-title":"TAp63 induces senescence and suppresses tumorigenesis in vivo","volume":"11","author":"Guo X","year":"2009","unstructured":"X Guo, , TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol 11, 1451\u20131457 (2009).","journal-title":"Nat Cell Biol"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1242\/dev.071191","article-title":"\u0394Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation","volume":"139","author":"Romano R-A","year":"2012","unstructured":"R-A Romano, , \u0394Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development 139, 772\u2013782 (2012).","journal-title":"Development"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1474-9726.2011.00743.x","article-title":"Stem cell depletion in Hutchinson-Gilford progeria syndrome","volume":"10","author":"Rosengardten Y","year":"2011","unstructured":"Y Rosengardten, T McKenna, D Grochov\u00e1, M Eriksson, Stem cell depletion in Hutchinson-Gilford progeria syndrome. Aging Cell 10, 1011\u20131020 (2011).","journal-title":"Aging Cell"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/stem.723","article-title":"TAp63 is important for cardiac differentiation of embryonic stem cells and heart development","volume":"29","author":"Rouleau M","year":"2011","unstructured":"M Rouleau, , TAp63 is important for cardiac differentiation of embryonic stem cells and heart development. Stem Cells 29, 1672\u20131683 (2011).","journal-title":"Stem Cells"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software","volume":"20","author":"de Hoon MJL","year":"2004","unstructured":"MJL de Hoon, S Imoto, J Nolan, S Miyano, Open source clustering software. Bioinformatics 20, 1453\u20131454 (2004).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","article-title":"Java Treeview\u2013Extensible visualization of microarray data","volume":"20","author":"Saldanha AJ","year":"2004","unstructured":"AJ Saldanha, Java Treeview\u2013Extensible visualization of microarray data. Bioinformatics 20, 3246\u20133248 (2004).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean CY","year":"2010","unstructured":"CY McLean, , GREAT improves functional interpretation of cis-regulatory regions. Nat Biotechnol 28, 495\u2013501 (2010).","journal-title":"Nat Biotechnol"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1711613114","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1711613114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T12:51:16Z","timestamp":1654606276000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1711613114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":49,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2017,12,19]]}},"alternative-id":["10.1073\/pnas.1711613114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1711613114","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732219442.793549650","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"2017-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}