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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,3,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Severe complications of malaria, such as anemia and cerebral malaria (CM) (neuroinflammation), are responsible for \u223c25% of infant mortality in certain regions of Africa. Notwithstanding current effective antiplasmodial treatment, drug resistance is on the increase in the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites, and therapy to treat CM is nonexistent. Here, we show that rocaglates derived from a natural product originally identified from plants of the\n                    <jats:italic>Aglaia<\/jats:italic>\n                    species, effectively block blood-stage parasite replication in several mouse models and in infected human RBCs. Importantly, neurological inflammation is mitigated and survival is promoted in experimental CM, highlighting the strong potential of this class of compounds to treat complicated malaria.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1713000115","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T14:36:25Z","timestamp":1519137385000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Rocaglates as dual-targeting agents for experimental cerebral malaria"],"prefix":"10.1073","volume":"115","author":[{"given":"David","family":"Langlais","sequence":"first","affiliation":[{"name":"Department of Biochemistry, McGill University, Montreal, QC, H3G 0B1 Canada;"},{"name":"McGill University Research Center on Complex Traits, McGill University, Montreal, QC, H3G 0B1 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