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Evidence is growing that this heterogeneity may be influenced by the heterogeneous molecular architecture of misfolded amyloid-\u03b2 peptide (A\u03b2) in the brain. To test this hypothesis, we used unique fluorescent ligands to interrogate the molecular structure of A\u03b2 in amyloid plaques from patients who had died with etiologically distinct subtypes of AD. We found that A\u03b2-amyloid plaques in the brain cluster as clouds of conformational variants that differ among certain subtypes of AD. 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