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Using this method, we identified four Food and Drug Administration-approved drugs with specific effects on cells deficient for the TSC1 and TSC2 tumor suppressor genes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1713362114","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T13:36:17Z","timestamp":1511876177000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Improved detection of synthetic lethal interactions in\n                    <i>Drosophila<\/i>\n                    cells using variable dose analysis (VDA)"],"prefix":"10.1073","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9134-4279","authenticated-orcid":false,"given":"Benjamin E.","family":"Housden","sequence":"first","affiliation":[{"name":"Living Systems Institute, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom EX4 4QD;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongchi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Valvezan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard T. 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