{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:54:00Z","timestamp":1783040040557,"version":"3.54.6"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"49","license":[{"start":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:00:00Z","timestamp":1527379200000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFA0505800"],"award-info":[{"award-number":["2017YFA0505800"]}]},{"name":"National Key R&D Program of China","award":["2016YFA0502102"],"award-info":[{"award-number":["2016YFA0502102"]}]},{"name":"National Key R&D Program of China","award":["and 2014CB910103"],"award-info":[{"award-number":["and 2014CB910103"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31630045"],"award-info":[{"award-number":["31630045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31521091"],"award-info":[{"award-number":["31521091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["and 91429304"],"award-info":[{"award-number":["and 91429304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,12,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    IFN\u03b3 is a cytokine that induces various downstream genes for host defense against pathogens. How IFN\u03b3 induces downstream genes via the classical JAK1-STAT1 pathway is well understood, but how IFN\u03b3 induces a subset of downstream genes via the kinase IKK\u03b2 remains enigmatic. We identified SNX8 protein as an important component of this IFN\u03b3-triggered noncanonical pathway. SNX8 deficiency impairs IFN\u03b3-triggered induction of a subset of downstream genes, rendering the mouse more susceptible to infection of intracellular bacteria\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    . Mechanistically, IFN\u03b3 induces phosphorylation of SNX8, which promotes the recruitment of IKK\u03b2 to the JAK1 complex and subsequent activation of IKK\u03b2. Our findings suggest that SNX8 acts as a link for IFN\u03b3-triggered noncanonical signaling pathway and host defense against intracellular bacteria infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1713462114","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T15:01:44Z","timestamp":1511794904000},"page":"13000-13005","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["SNX8 mediates IFN\u03b3-triggered noncanonical signaling pathway and host defense against\n                    <i>Listeria monocytogenes<\/i>"],"prefix":"10.1073","volume":"114","author":[{"given":"Jin","family":"Wei","sequence":"first","affiliation":[{"name":"Medical Research Institute, Wuhan University, Wuhan, China, 430071;"},{"name":"College of Life Sciences, Wuhan University, Wuhan, China, 430071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Wuhan University, Wuhan, China, 430071;"},{"name":"College of Life Sciences, Wuhan University, Wuhan, China, 430071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Lian","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Wuhan University, Wuhan, China, 430071;"},{"name":"College of Life Sciences, Wuhan University, Wuhan, China, 430071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Wuhan University, Wuhan, China, 430071;"},{"name":"College of Life Sciences, Wuhan University, Wuhan, China, 430071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Wuhan University, Wuhan, China, 430071;"},{"name":"College of Life Sciences, Wuhan University, Wuhan, China, 430071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Wuhan University, Wuhan, China, 430071;"},{"name":"College of Life Sciences, Wuhan University, Wuhan, China, 430071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bing","family":"Shu","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Wuhan University, Wuhan, China, 430071;"},{"name":"College of Life Sciences, Wuhan University, Wuhan, China, 430071"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.009"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201711"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2422"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3691"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203481"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.017"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403530200"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.267"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105070200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00029"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.08.008"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.623"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401593101"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00050"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0034"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.09.007"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12324"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2300"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0209-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.09.076"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.056"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.09.077"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm974"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.1.690-702.1993"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111226"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1360"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09853"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5339.860"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801794105"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.07.012"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.955441"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501111"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3510"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247005"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1713462114","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1713462114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:47:03Z","timestamp":1649818023000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1713462114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":35,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2017,12,5]]}},"alternative-id":["10.1073\/pnas.1713462114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1713462114","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]},"assertion":[{"value":"2017-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}