{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:57:40Z","timestamp":1792627060588,"version":"4.5.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"2","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI053330"],"award-info":[{"award-number":["AI053330"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["6-FY14-453"],"award-info":[{"award-number":["6-FY14-453"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006509","name":"VSB Fonds","doi-asserted-by":"publisher","award":["2014"],"award-info":[{"award-number":["2014"]}],"id":[{"id":"10.13039\/501100006509","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Ministry of Education and Science | Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/33885\/2009"],"award-info":[{"award-number":["SFRH\/BD\/33885\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Successful pregnancy requires establishment of immune tolerance for invading fetal trophoblasts, as well as immunity to a variety of pathogens that cause placental and congenital infections. Decidual CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are key cells for recognition and response to foreign fetal, placental, and viral antigens at the maternal\u2013fetal interface. Thus, regulation of decidual CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation and cytotoxicity is crucial for a healthy pregnancy. Here, we demonstrate that decidual CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells have a mixed profile of T cell dysfunction, activation, and effector function, which allows for both immune tolerance and immunity. This is of great relevance for understanding the development of pregnancy complications as well as prevention of congenital infections that occur as result of impaired placental immunity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1713957115","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T13:18:54Z","timestamp":1513689534000},"page":"385-390","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":143,"title":["Mixed signature of activation and dysfunction allows human decidual CD8\n                    <sup>+<\/sup>\n                    T cells to provide both tolerance and immunity"],"prefix":"10.1073","volume":"115","author":[{"given":"Anita","family":"van der Zwan","sequence":"first","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;"},{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children\u2019s Hospital, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol R.","family":"Norwitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Tufts Medical Center, Boston, MA 02111;"},{"name":"Mother Infant Research Institute, Tufts Medical Center, Boston, MA 02111;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-8190","authenticated-orcid":false,"given":"\u00c2ngela C.","family":"Crespo","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans H. J.","family":"Claas","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack L.","family":"Strominger","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Tilburgs","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/aji.12094","article-title":"CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity","volume":"69","author":"Tilburgs T","year":"2013","unstructured":"T Tilburgs, JL Strominger, CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity. Am J Reprod Immunol 69, 395\u2013407 (2013).","journal-title":"Am J Reprod Immunol"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.immunol.21.120601.141110","article-title":"T cell anergy","volume":"21","author":"Schwartz RH","year":"2003","unstructured":"RH Schwartz, T cell anergy. Annu Rev Immunol 21, 305\u2013334 (2003).","journal-title":"Annu Rev Immunol"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cell.2009.06.036","article-title":"Redefining chronic viral infection","volume":"138","author":"Virgin HW","year":"2009","unstructured":"HW Virgin, EJ Wherry, R Ahmed, Redefining chronic viral infection. Cell 138, 30\u201350 (2009).","journal-title":"Cell"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular signature of CD8+ T cell exhaustion during chronic viral infection","volume":"27","author":"Wherry EJ","year":"2007","unstructured":"EJ Wherry, , Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27, 670\u2013684 (2007).","journal-title":"Immunity"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1182\/blood-2006-09-044826","article-title":"PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors","volume":"109","author":"Zhang JY","year":"2007","unstructured":"JY Zhang, , PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood 109, 4671\u20134678 (2007).","journal-title":"Blood"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1182\/blood-2008-12-195792","article-title":"Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired","volume":"114","author":"Ahmadzadeh M","year":"2009","unstructured":"M Ahmadzadeh, , Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 114, 1537\u20131544 (2009).","journal-title":"Blood"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac AJ","year":"1998","unstructured":"AJ Zajac, , Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 188, 2205\u20132213 (1998).","journal-title":"J Exp Med"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1084\/jem.187.9.1383","article-title":"Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes","volume":"187","author":"Gallimore A","year":"1998","unstructured":"A Gallimore, , Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med 187, 1383\u20131393 (1998).","journal-title":"J Exp Med"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.4049\/jimmunol.1401771","article-title":"Protective efficacy of individual CD8+ T cell specificities in chronic viral infection","volume":"194","author":"Johnson S","year":"2015","unstructured":"S Johnson, , Protective efficacy of individual CD8+ T cell specificities in chronic viral infection. J Immunol 194, 1755\u20131762 (2015).","journal-title":"J Immunol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1084\/jem.20031982","article-title":"Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection","volume":"199","author":"Draenert R","year":"2004","unstructured":"R Draenert, , Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J Exp Med 199, 905\u2013915 (2004).","journal-title":"J Exp Med"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1084\/jem.20041006","article-title":"CD8 epitope escape and reversion in acute HCV infection","volume":"200","author":"Timm J","year":"2004","unstructured":"J Timm, , CD8 epitope escape and reversion in acute HCV infection. J Exp Med 200, 1593\u20131604 (2004).","journal-title":"J Exp Med"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1002\/eji.201545495","article-title":"Molecular characterization of HCMV-specific immune responses: Parallels between CD8(+) T cells, CD4(+) T cells, and NK cells","volume":"45","author":"Vieira Braga FA","year":"2015","unstructured":"FA Vieira Braga, KM Hertoghs, RA van Lier, KP van Gisbergen, Molecular characterization of HCMV-specific immune responses: Parallels between CD8(+) T cells, CD4(+) T cells, and NK cells. Eur J Immunol 45, 2433\u20132445 (2015).","journal-title":"Eur J Immunol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/bjc.2014.416","article-title":"PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients","volume":"111","author":"Wu X","year":"2014","unstructured":"X Wu, , PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients. Br J Cancer 111, 1391\u20131399 (2014).","journal-title":"Br J Cancer"},{"key":"e_1_3_4_14_2","article-title":"Immune checkpoint blockade in infectious diseases","author":"Wykes MN","year":"2017","unstructured":"MN Wykes, SR Lewin, Immune checkpoint blockade in infectious diseases. Nat Rev Immunol, October 9, 2017).","journal-title":"Nat Rev Immunol"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev-immunol-032414-112049","article-title":"Coinhibitory pathways in immunotherapy for cancer","volume":"34","author":"Baumeister SH","year":"2016","unstructured":"SH Baumeister, GJ Freeman, G Dranoff, AH Sharpe, Coinhibitory pathways in immunotherapy for cancer. Annu Rev Immunol 34, 539\u2013573 (2016).","journal-title":"Annu Rev Immunol"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.cell.2016.08.052","article-title":"A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells","volume":"166","author":"Singer M","year":"2016","unstructured":"M Singer, , A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells. Cell 166, 1500\u20131511.e9 (2016).","journal-title":"Cell"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.bi.55.070186.004405","article-title":"Metallothionein","volume":"55","author":"Hamer DH","year":"1986","unstructured":"DH Hamer, Metallothionein. Annu Rev Biochem 55, 913\u2013951 (1986).","journal-title":"Annu Rev Biochem"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1095\/biolreprod.106.052654","article-title":"Effector activity of decidual CD8+ T lymphocytes in early human pregnancy","volume":"75","author":"Scaife PJ","year":"2006","unstructured":"PJ Scaife, JN Bulmer, SC Robson, BA Innes, RF Searle, Effector activity of decidual CD8+ T lymphocytes in early human pregnancy. Biol Reprod 75, 562\u2013567 (2006).","journal-title":"Biol Reprod"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1073\/pnas.1507977112","article-title":"Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes","volume":"112","author":"Tilburgs T","year":"2015","unstructured":"T Tilburgs, , Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. Proc Natl Acad Sci USA 112, 7219\u20137224 (2015).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"e1738","DOI":"10.1038\/cddis.2015.112","article-title":"PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy","volume":"6","author":"Wang SC","year":"2015","unstructured":"SC Wang, , PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy. Cell Death Dis 6, e1738 (2015).","journal-title":"Cell Death Dis"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1095\/biolreprod.107.066324","article-title":"Expression and function of PDCD1 at the human maternal-fetal interface","volume":"79","author":"Taglauer ES","year":"2008","unstructured":"ES Taglauer, AS Trikhacheva, JG Slusser, MG Petroff, Expression and function of PDCD1 at the human maternal-fetal interface. Biol Reprod 79, 562\u2013569 (2008).","journal-title":"Biol Reprod"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.4049\/jimmunol.0903597","article-title":"Human decidual tissue contains differentiated CD8+ effector-memory T cells with unique properties","volume":"185","author":"Tilburgs T","year":"2010","unstructured":"T Tilburgs, , Human decidual tissue contains differentiated CD8+ effector-memory T cells with unique properties. J Immunol 185, 4470\u20134477 (2010).","journal-title":"J Immunol"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/plac.1999.0496","article-title":"Surface expression of HLA-C antigen by human extravillous trophoblast","volume":"21","author":"King A","year":"2000","unstructured":"A King, , Surface expression of HLA-C antigen by human extravillous trophoblast. Placenta 21, 376\u2013387 (2000).","journal-title":"Placenta"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ajpath.2011.09.021","article-title":"Minor histocompatibility antigens are expressed in syncytiotrophoblast and trophoblast debris: Implications for maternal alloreactivity to the fetus","volume":"180","author":"Holland OJ","year":"2012","unstructured":"OJ Holland, , Minor histocompatibility antigens are expressed in syncytiotrophoblast and trophoblast debris: Implications for maternal alloreactivity to the fetus. Am J Pathol 180, 256\u2013266 (2012).","journal-title":"Am J Pathol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/oxfordjournals.humrep.a137430","article-title":"Granulated lymphocytes in human endometrium: Histochemical and immunohistochemical studies","volume":"6","author":"Bulmer JN","year":"1991","unstructured":"JN Bulmer, L Morrison, M Longfellow, A Ritson, D Pace, Granulated lymphocytes in human endometrium: Histochemical and immunohistochemical studies. Hum Reprod 6, 791\u2013798 (1991).","journal-title":"Hum Reprod"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.4049\/jimmunol.179.7.4383","article-title":"Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy","volume":"179","author":"Constantin CM","year":"2007","unstructured":"CM Constantin, , Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy. J Immunol 179, 4383\u20134389 (2007).","journal-title":"J Immunol"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/cmi.2014.84","article-title":"Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy","volume":"11","author":"Clark DR","year":"2014","unstructured":"DR Clark, , Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy. Cell Mol Immunol 11, 595\u2013605 (2014).","journal-title":"Cell Mol Immunol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.4049\/jimmunol.0804018","article-title":"Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy","volume":"182","author":"Moldenhauer LM","year":"2009","unstructured":"LM Moldenhauer, , Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy. J Immunol 182, 8080\u20138093 (2009).","journal-title":"J Immunol"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0198-8859(01)00209-9","article-title":"Pregnancy can induce long-persisting primed CTLs specific for inherited paternal HLA antigens","volume":"62","author":"van Kampen CA","year":"2001","unstructured":"CA van Kampen, , Pregnancy can induce long-persisting primed CTLs specific for inherited paternal HLA antigens. Hum Immunol 62, 201\u2013207 (2001).","journal-title":"Hum Immunol"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1182\/blood-2003-05-1625","article-title":"Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: Implications for stem cell transplantation and immunotherapy","volume":"103","author":"Verdijk RM","year":"2004","unstructured":"RM Verdijk, , Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: Implications for stem cell transplantation and immunotherapy. Blood 103, 1961\u20131964 (2004).","journal-title":"Blood"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jri.2016.03.003","article-title":"HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriage","volume":"116","author":"Meuleman T","year":"2016","unstructured":"T Meuleman, , HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriage. J Reprod Immunol 116, 28\u201334 (2016).","journal-title":"J Reprod Immunol"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1093\/humrep\/der327","article-title":"Cytomegalovirus sero positivity dramatically alters the maternal CD8+ T cell repertoire and leads to the accumulation of highly differentiated memory cells during human pregnancy","volume":"26","author":"Lissauer D","year":"2011","unstructured":"D Lissauer, , Cytomegalovirus sero positivity dramatically alters the maternal CD8+ T cell repertoire and leads to the accumulation of highly differentiated memory cells during human pregnancy. Hum Reprod 26, 3355\u20133365 (2011).","journal-title":"Hum Reprod"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2015.09.073","article-title":"The possible role of virus-specific CD8(+) memory T cells in decidual tissue","volume":"113","author":"van Egmond A","year":"2016","unstructured":"A van Egmond, C van der Keur, GM Swings, SA Scherjon, FH Claas, The possible role of virus-specific CD8(+) memory T cells in decidual tissue. J Reprod Immunol 113, 1\u20138 (2016).","journal-title":"J Reprod Immunol"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.4049\/jimmunol.178.7.4112","article-title":"Four functionally distinct populations of human effector-memory CD8+ T lymphocytes","volume":"178","author":"Romero P","year":"2007","unstructured":"P Romero, , Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J Immunol 178, 4112\u20134119 (2007).","journal-title":"J Immunol"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian A","year":"2005","unstructured":"A Subramanian, , Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102, 15545\u201315550 (2005).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.immuni.2015.12.006","article-title":"Compendium of immune signatures identifies conserved and species-specific biology in response to inflammation","volume":"44","author":"Godec J","year":"2016","unstructured":"J Godec, , Compendium of immune signatures identifies conserved and species-specific biology in response to inflammation. Immunity 44, 194\u2013206 (2016).","journal-title":"Immunity"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.immuni.2014.06.011","article-title":"Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells","volume":"41","author":"Wu C","year":"2014","unstructured":"C Wu, , Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 41, 270\u2013282 (2014).","journal-title":"Immunity"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"5566","DOI":"10.1210\/en.2007-0517","article-title":"Interleukin-11 promotes migration, but not proliferation, of human trophoblast cells, implying a role in placentation","volume":"148","author":"Paiva P","year":"2007","unstructured":"P Paiva, , Interleukin-11 promotes migration, but not proliferation, of human trophoblast cells, implying a role in placentation. Endocrinology 148, 5566\u20135572 (2007).","journal-title":"Endocrinology"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1073\/pnas.1617927114","article-title":"Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection","volume":"113","author":"Crespo AC","year":"2016","unstructured":"AC Crespo, JL Strominger, T Tilburgs, Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection. Proc Natl Acad Sci USA 113, 15072\u201315077 (2016).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1189\/jlb.1A0316-135R","article-title":"Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long-lived maternal T cells","volume":"101","author":"Barton BM","year":"2017","unstructured":"BM Barton, R Xu, EJ Wherry, PM Porrett, Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long-lived maternal T cells. J Leukoc Biol 101, 975\u2013987 (2017).","journal-title":"J Leukoc Biol"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1073\/pnas.1517724112","article-title":"The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface","volume":"112","author":"Tilburgs T","year":"2015","unstructured":"T Tilburgs, JH Evans, AC Crespo, JL Strominger, The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface. Proc Natl Acad Sci USA 112, 13312\u201313317 (2015).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"15563","DOI":"10.1073\/pnas.0507835102","article-title":"Human decidual NK cells form immature activating synapses and are not cytotoxic","volume":"102","author":"Kopcow HD","year":"2005","unstructured":"HD Kopcow, , Human decidual NK cells form immature activating synapses and are not cytotoxic. Proc Natl Acad Sci USA 102, 15563\u201315568 (2005).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"e1003257, and e","DOI":"10.1371\/journal.ppat.1003257","article-title":"Human cytomegalovirus infection elicits new decidual natural killer cell effector functions","volume":"9","author":"Siewiera J","year":"2013","unstructured":"J Siewiera, , Human cytomegalovirus infection elicits new decidual natural killer cell effector functions. PLoS Pathog 9, e1003257, and erratum (2013) 9:10.1371 (2013).","journal-title":"PLoS Pathog"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"18608","DOI":"10.1073\/pnas.1317191110","article-title":"MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation","volume":"110","author":"Trifari S","year":"2013","unstructured":"S Trifari, , MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation. Proc Natl Acad Sci USA 110, 18608\u201318613 (2013).","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1713957115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1713957115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T14:05:06Z","timestamp":1654610706000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1713957115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1,9]]}},"alternative-id":["10.1073\/pnas.1713957115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1713957115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,19]]},"assertion":[{"value":"2017-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}