{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:36:32Z","timestamp":1781109392311,"version":"3.54.1"},"reference-count":19,"publisher":"National Academy of Sciences","issue":"51","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["AID-GH-F-15-00012"],"award-info":[{"award-number":["AID-GH-F-15-00012"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,12,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Neonatal jaundice, a condition caused by the accumulation of bilirubin in the bloodstream, affects approximately half of all newborns. In high-resource settings, babies with elevated serum bilirubin levels are identified through routine hospital laboratory testing. When identified, jaundice is easily treated using blue-light phototherapy. Low-cost, rugged phototherapy lights have been developed and shown to be effective in low-resource settings. However, jaundice regularly goes undetected in these settings due to a lack of diagnostic tools to measure bilirubin levels. Left untreated, jaundice can lead to permanent neurological damage and mortality, the vast majority of which currently occurs in low-resource settings. In this paper, we present a low-cost method to measure total bilirubin at the point of care in low-resource settings.<\/jats:p>","DOI":"10.1073\/pnas.1714020114","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T14:55:14Z","timestamp":1512399314000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings"],"prefix":"10.1073","volume":"114","author":[{"given":"Pelham A.","family":"Keahey","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu L.","family":"Simeral","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer J.","family":"Schroder","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan M.","family":"Bond","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prince J.","family":"Mtenthaonnga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Miros","sequence":"additional","affiliation":[{"name":"3rd Stone Design, San Rafael, CA 94901"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queen","family":"Dube","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-9467","authenticated-orcid":false,"given":"Rebecca R.","family":"Richards-Kortum","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.208"},{"key":"e_1_3_3_2_2","volume-title":"Born Too Soon: The Global Action Report on Preterm Birth","author":"March of Dimes, The Partnership for Maternal, Newborn & Child Health, Save the Children, World Health Organization","year":"2012","unstructured":"; March of Dimes, The Partnership for Maternal, Newborn & Child Health, Save the Children, World Health Organization Born Too Soon: The Global Action Report on Preterm Birth (WHO, Geneva, 2012)."},{"key":"e_1_3_3_3_2","volume-title":"Recommendations for Management of Common Childhood Conditions: Evidence for Technical Update of Pocket Book Recommendations: Newborn Conditions, Dysentery, Pneumonia, Oxygen Use and Delivery, Common Causes of Fever, Severe Acute Malnutrition and Supportive Care","author":"World Health Organization","year":"2012","unstructured":"; World Health Organization Recommendations for Management of Common Childhood Conditions: Evidence for Technical Update of Pocket Book Recommendations: Newborn Conditions, Dysentery, Pneumonia, Oxygen Use and Delivery, Common Causes of Fever, Severe Acute Malnutrition and Supportive Care (WHO, Geneva, 2012)."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)72329-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/31.11.1779"},{"key":"e_1_3_3_6_2","first-page":"198","article-title":"Measurement of bilirubin and its monoconjugates and diconjugates in human serum by alkaline methanolysis and high-performance liquid chromatography","volume":"96","author":"Blanckaert N","year":"1980","unstructured":"N Blanckaert, , Measurement of bilirubin and its monoconjugates and diconjugates in human serum by alkaline methanolysis and high-performance liquid chromatography. 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