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U.S.A."],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The cancer anorexia cachexia syndrome (CACS) is a condition characterized by skeletal muscle degradation with no effective treatment. CACS is particularly prevalent in patients with nonsmall cell lung cancer, where it reduces quality of life and increases mortality. Using an inducible lung cancer model, we characterize the changes in intermediary metabolism that occur during CACS in mice. We identify a unique serum metabolite profile consisting of low ketones and increased glucocorticoid levels. Hypoketonemia is associated with reduced expression of hepatic peroxisome proliferator-activated receptor-\u03b1 (PPAR\u03b1) targets that regulate fatty acid oxidation and ketogenesis. Replacing ketone production using the PPAR\u03b1 agonist, fenofibrate, reduced glucocorticoid levels, prevented skeletal muscle wasting, and minimized weight loss. These exciting results provide important preclinical data toward a therapeutic strategy.<\/jats:p>","DOI":"10.1073\/pnas.1714703115","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T15:28:09Z","timestamp":1515425289000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["Fenofibrate prevents skeletal muscle loss in mice with lung cancer"],"prefix":"10.1073","volume":"115","author":[{"given":"Marcus D.","family":"Goncalves","sequence":"first","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Kyoung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Pauli","sequence":"additional","affiliation":[{"name":"Institute for Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Cheng","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wu","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Loughran","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke M.","family":"Emerling","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"},{"name":"CSHL Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis C.","family":"Cantley","sequence":"additional","affiliation":[{"name":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;"},{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon K","year":"2011","unstructured":"K Fearon, , Definition and classification of cancer cachexia: An international consensus. 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