{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:13:27Z","timestamp":1787062407588,"version":"build-2736575974"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"7","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2013CB911304"],"award-info":[{"award-number":["2013CB911304"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation of the people's republic of china","award":["331372208"],"award-info":[{"award-number":["331372208"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["U1302221"],"award-info":[{"award-number":["U1302221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDA12040209"],"award-info":[{"award-number":["XDA12040209"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["QYZDJ-SSW-SMC012"],"award-info":[{"award-number":["QYZDJ-SSW-SMC012"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan province","award":["2015HA023"],"award-info":[{"award-number":["2015HA023"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31640071"],"award-info":[{"award-number":["31640071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDA12020334"],"award-info":[{"award-number":["XDA12020334"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["Youth Innovation Promotion Association"],"award-info":[{"award-number":["Youth Innovation Promotion Association"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Province","award":["2016FA006"],"award-info":[{"award-number":["2016FA006"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31470740"],"award-info":[{"award-number":["31470740"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,2,13]]},"abstract":"<jats:p>\n                    Centipedes can subdue giant prey by using venom, which is metabolically expensive to synthesize and thus used frugally through efficiently disrupting essential physiological systems. Here, we show that a centipede (\n                    <jats:italic>Scolopendra subspinipes mutilans<\/jats:italic>\n                    , \u223c3 g) can subdue a mouse (\u223c45 g) within 30 seconds. We found that this observation is largely due to a peptide toxin in the venom, SsTx, and further established that SsTx blocks KCNQ potassium channels to exert the lethal toxicity. We also demonstrated that a KCNQ opener, retigabine, neutralizes the toxicity of a centipede\u2019s venom. The study indicates that centipedes\u2019 venom has evolved to simultaneously disrupt cardiovascular, respiratory, muscular, and nervous systems by targeting the broadly distributed KCNQ channels, thus providing a therapeutic strategy for centipede envenomation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1714760115","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:06:11Z","timestamp":1516633571000},"page":"1646-1651","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Centipedes subdue giant prey by blocking KCNQ channels"],"prefix":"10.1073","volume":"115","author":[{"given":"Lei","family":"Luo","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangming","family":"Wu","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China;"},{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230027, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China;"},{"name":"Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China;"},{"name":"Institute of Translational Medicine, Zhejiang University, Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Ombati","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Chen","sequence":"additional","affiliation":[{"name":"Chongzhou People\u2019s Hospital, Sichuan Academy of Medical Sciences, Chengdu 611230, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiancui","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Cui","sequence":"additional","affiliation":[{"name":"Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;"},{"name":"Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St Louis, St. Louis, MO 63130;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiumin","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China;"},{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230027, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;"},{"name":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlin","family":"Tian","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China;"},{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230027, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilong","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Lai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"},{"name":"Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"1","article-title":"Behaviour and ecology of the American kestrel (Falco sparverius L.) in the Sierra Nevada of California","volume":"103","author":"Balgooyen TC","year":"1976","unstructured":"TC Balgooyen, Behaviour and ecology of the American kestrel (Falco sparverius L.) in the Sierra Nevada of California. Univ Calif Publ Zool 103, 1\u201384 (1976).","journal-title":"Univ Calif Publ Zool"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1086\/283666","article-title":"Foraging costs and relative prey size","volume":"116","author":"Griffiths D","year":"1980","unstructured":"D Griffiths, Foraging costs and relative prey size. Am Nat 116, 743\u2013752 (1980).","journal-title":"Am Nat"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0163-7258(92)90009-O","article-title":"Venomous mammals","volume":"53","author":"Dufton MJ","year":"1992","unstructured":"MJ Dufton, Venomous mammals. Pharmacol Ther 53, 199\u2013215 (1992).","journal-title":"Pharmacol Ther"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.toxicon.2011.01.004","article-title":"On the venom system of centipedes (Chilopoda), a neglected group of venomous animals","volume":"57","author":"Undheim EAB","year":"2011","unstructured":"EAB Undheim, GF King, On the venom system of centipedes (Chilopoda), a neglected group of venomous animals. Toxicon 57, 512\u2013524 (2011).","journal-title":"Toxicon"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1163\/1570754043492135","article-title":"Enzyme activities and biological functions of snake venoms","volume":"2","author":"McCue MD","year":"2005","unstructured":"MD McCue, Enzyme activities and biological functions of snake venoms. Appl Herpetol 2, 109\u2013123 (2005).","journal-title":"Appl Herpetol"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1643\/0045-8511(2006)6[818:COPVIT]2.0.CO;2","article-title":"Cost of producing venom in three North American pitviper species","volume":"4","author":"McCue MD","year":"2006","unstructured":"MD McCue, Cost of producing venom in three North American pitviper species. Copeia 4, 818\u2013825 (2006).","journal-title":"Copeia"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.toxicon.2012.11.022","article-title":"The venom optimization hypothesis revisited","volume":"63","author":"Morgenstern D","year":"2013","unstructured":"D Morgenstern, GF King, The venom optimization hypothesis revisited. Toxicon 63, 120\u2013128 (2013).","journal-title":"Toxicon"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-ento-120811-153650","article-title":"Spider-venom peptides: Structure, pharmacology, and potential for control of insect pests","volume":"58","author":"King GF","year":"2013","unstructured":"GF King, MC Hardy, Spider-venom peptides: Structure, pharmacology, and potential for control of insect pests. Annu Rev Entomol 58, 475\u2013496 (2013).","journal-title":"Annu Rev Entomol"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000438449","article-title":"Prey-capture strategies of fish-hunting cone snails: Behavior, neurobiology and evolution","volume":"86","author":"Olivera BM","year":"2015","unstructured":"BM Olivera, J Seger, MP Horvath, AE Fedosov, Prey-capture strategies of fish-hunting cone snails: Behavior, neurobiology and evolution. Brain Behav Evol 86, 58\u201374 (2015).","journal-title":"Brain Behav Evol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.3390\/toxins7114832","article-title":"Centipede venoms and their components: Resources for potential therapeutic applications","volume":"7","author":"Hakim MA","year":"2015","unstructured":"MA Hakim, S Yang, R Lai, Centipede venoms and their components: Resources for potential therapeutic applications. Toxins (Basel) 7, 4832\u20134851 (2015).","journal-title":"Toxins (Basel)"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1074\/mcp.M112.018853","article-title":"Chemical punch packed in venoms makes centipedes excellent predators","volume":"11","author":"Yang S","year":"2012","unstructured":"S Yang, , Chemical punch packed in venoms makes centipedes excellent predators. Mol Cell Proteomics 11, 640\u2013650 (2012).","journal-title":"Mol Cell Proteomics"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1038\/ncomms9297","article-title":"A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1","volume":"6","author":"Yang S","year":"2015","unstructured":"S Yang, , A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1. Nat Commun 6, 8297 (2015).","journal-title":"Nat Commun"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1093\/molbev\/msu162","article-title":"Clawing through evolution: Toxin diversification and convergence in the ancient lineage Chilopoda (centipedes)","volume":"31","author":"Undheim EA","year":"2014","unstructured":"EA Undheim, , Clawing through evolution: Toxin diversification and convergence in the ancient lineage Chilopoda (centipedes). Mol Biol Evol 31, 2124\u20132148 (2014).","journal-title":"Mol Biol Evol"},{"key":"e_1_3_4_14_2","first-page":"125","article-title":"Centipede bites in Hawai\u2019i: A brief case report and review of the literature","volume":"66","author":"Guerrero AP","year":"2007","unstructured":"AP Guerrero, Centipede bites in Hawai\u2019i: A brief case report and review of the literature. Hawaii Med J 66, 125\u2013127 (2007).","journal-title":"Hawaii Med J"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1520\/JFS14565J","article-title":"Centipede inflicted postmortem injury","volume":"44","author":"Harada K","year":"1999","unstructured":"K Harada, K Asa, T Imachi, Y Yamaguchi, K Yoshida, Centipede inflicted postmortem injury. J Forensic Sci 44, 849\u2013850 (1999).","journal-title":"J Forensic Sci"},{"key":"e_1_3_4_16_2","first-page":"549","article-title":"Rhabdomyolysis and acute renal failure following the bite of the giant desert centipede Scolopendra heros","volume":"142","author":"Logan JL","year":"1985","unstructured":"JL Logan, DA Ogden, Rhabdomyolysis and acute renal failure following the bite of the giant desert centipede Scolopendra heros. West J Med 142, 549\u2013550 (1985).","journal-title":"West J Med"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1580\/1080-6032(2004)015[0109:ACIFCE]2.0.CO;2","article-title":"Acute coronary ischemia following centipede envenomation: Case report and review of the literature","volume":"15","author":"Ozsarac M","year":"2004","unstructured":"M Ozsarac, O Karcioglu, C Ayrik, F Somuncu, S Gumrukcu, Acute coronary ischemia following centipede envenomation: Case report and review of the literature. Wilderness Environ Med 15, 109\u2013112 (2004).","journal-title":"Wilderness Environ Med"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1136\/emj.2005.030007","article-title":"Acute myocardial infarction in a young man caused by centipede sting","volume":"23","author":"Yildiz A","year":"2006","unstructured":"A Yildiz, , Acute myocardial infarction in a young man caused by centipede sting. Emerg Med J 23, e30 (2006).","journal-title":"Emerg Med J"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrn1785","article-title":"Pathways modulating neural KCNQ\/M (Kv7) potassium channels","volume":"6","author":"Delmas P","year":"2005","unstructured":"P Delmas, DA Brown, Pathways modulating neural KCNQ\/M (Kv7) potassium channels. Nat Rev Neurosci 6, 850\u2013862 (2005).","journal-title":"Nat Rev Neurosci"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35036198","article-title":"Neuronal KCNQ potassium channels: Physiology and role in disease","volume":"1","author":"Jentsch TJ","year":"2000","unstructured":"TJ Jentsch, Neuronal KCNQ potassium channels: Physiology and role in disease. Nat Rev Neurosci 1, 21\u201330 (2000).","journal-title":"Nat Rev Neurosci"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"L476","DOI":"10.1152\/ajplung.00253.2013","article-title":"KCNQ (Kv7) potassium channel activators as bronchodilators: Combination with a \u03b22-adrenergic agonist enhances relaxation of rat airways","volume":"306","author":"Brueggemann LI","year":"2014","unstructured":"LI Brueggemann, , KCNQ (Kv7) potassium channel activators as bronchodilators: Combination with a \u03b22-adrenergic agonist enhances relaxation of rat airways. Am J Physiol Lung Cell Mol Physiol 306, L476\u2013L486 (2014).","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"e11331","DOI":"10.1371\/journal.pone.0011331","article-title":"Arboreal ants use the \u201cVelcro(R) principle\u201d to capture very large prey","volume":"5","author":"Dejean A","year":"2010","unstructured":"A Dejean, , Arboreal ants use the \u201cVelcro(R) principle\u201d to capture very large prey. PLoS One 5, e11331 (2010).","journal-title":"PLoS One"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1073\/pnas.0710603105","article-title":"Cooperative capture of large prey solves scaling challenge faced by spider societies","volume":"105","author":"Yip EC","year":"2008","unstructured":"EC Yip, KS Powers, L Avil\u00e9s, Cooperative capture of large prey solves scaling challenge faced by spider societies. Proc Natl Acad Sci USA 105, 11818\u201311822 (2008).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_24_2","first-page":"307","article-title":"Cooperative foraging for large prey by Paratemnus-Elongatus (Pseudoscorpionida, Atemnidae)","volume":"18","author":"Zeh JA","year":"1990","unstructured":"JA Zeh, DW Zeh, Cooperative foraging for large prey by Paratemnus-Elongatus (Pseudoscorpionida, Atemnidae). J Arachnol 18, 307\u2013311 (1990).","journal-title":"J Arachnol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00114-014-1189-8","article-title":"David and Goliath: Potent venom of an ant-eating spider (Araneae) enables capture of a giant prey","volume":"101","author":"Pek\u00e1r S","year":"2014","unstructured":"S Pek\u00e1r, O \u0160edo, E L\u00edznarov\u00e1, S Korenko, Z Zdr\u00e1hal, David and Goliath: Potent venom of an ant-eating spider (Araneae) enables capture of a giant prey. Naturwissenschaften 101, 533\u2013540 (2014).","journal-title":"Naturwissenschaften"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1085\/jgp.91.3.335","article-title":"Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel","volume":"91","author":"MacKinnon R","year":"1988","unstructured":"R MacKinnon, C Miller, Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. J Gen Physiol 91, 335\u2013349 (1988).","journal-title":"J Gen Physiol"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/HYPERTENSIONAHA.114.04373","article-title":"Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats","volume":"65","author":"Stott JB","year":"2015","unstructured":"JB Stott, V Barrese, TA Jepps, EV Leighton, IA Greenwood, Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats. Hypertension 65, 676\u2013682 (2015).","journal-title":"Hypertension"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1126\/science.7716527","article-title":"Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor","volume":"268","author":"Hidalgo P","year":"1995","unstructured":"P Hidalgo, R MacKinnon, Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science 268, 307\u2013310 (1995).","journal-title":"Science"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0022-2836(90)90275-Q","article-title":"Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins","volume":"214","author":"Horovitz A","year":"1990","unstructured":"A Horovitz, AR Fersht, Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins. J Mol Biol 214, 613\u2013617 (1990).","journal-title":"J Mol Biol"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0896-6273(00)80030-6","article-title":"Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis","volume":"16","author":"Ranganathan R","year":"1996","unstructured":"R Ranganathan, JH Lewis, R MacKinnon, Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron 16, 131\u2013139 (1996).","journal-title":"Neuron"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0022-2836(95)80064-6","article-title":"Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double mutant cycles","volume":"248","author":"Schreiber G","year":"1995","unstructured":"G Schreiber, AR Fersht, Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double mutant cycles. J Mol Biol 248, 478\u2013486 (1995).","journal-title":"J Mol Biol"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1111\/j.1755-5922.2010.00235.x","article-title":"Disruption of coronary vasomotor function: The coronary spasm syndrome","volume":"30","author":"Moukarbel GV","year":"2012","unstructured":"GV Moukarbel, LA Weinrauch, Disruption of coronary vasomotor function: The coronary spasm syndrome. Cardiovasc Ther 30, e66\u2013e73 (2012).","journal-title":"Cardiovasc Ther"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"2K","DOI":"10.1016\/S0002-9149(98)00531-1","article-title":"Metabolic derangement in ischemic heart disease and its therapeutic control","volume":"82","author":"Ferrari R","year":"1998","unstructured":"R Ferrari, , Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol 82, 2K\u201313K (1998).","journal-title":"Am J Cardiol"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0021-9258(18)45993-5","article-title":"Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom","volume":"267","author":"Crest M","year":"1992","unstructured":"M Crest, , Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom. J Biol Chem 267, 1640\u20131647 (1992).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"14819","DOI":"10.1074\/jbc.M412735200","article-title":"BmP09, a \u201clong chain\u201d scorpion peptide blocker of BK channels","volume":"280","author":"Yao J","year":"2005","unstructured":"J Yao, , BmP09, a \u201clong chain\u201d scorpion peptide blocker of BK channels. J Biol Chem 280, 14819\u201314828 (2005).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jprot.2015.02.012","article-title":"Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia","volume":"120","author":"Tan KY","year":"2015","unstructured":"KY Tan, CH Tan, SY Fung, NH Tan, Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia. J Proteomics 120, 105\u2013125 (2015).","journal-title":"J Proteomics"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.actatropica.2005.09.001","article-title":"Clinico-toxinological characterization of the acute effects of the venom of the marine snail, Conus loroisii","volume":"97","author":"Saminathan R","year":"2006","unstructured":"R Saminathan, , Clinico-toxinological characterization of the acute effects of the venom of the marine snail, Conus loroisii. Acta Trop 97, 75\u201387 (2006).","journal-title":"Acta Trop"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/ajmg.1582","article-title":"Ion channels and epilepsy","volume":"106","author":"Lerche H","year":"2001","unstructured":"H Lerche, K Jurkat-Rott, F Lehmann-Horn, Ion channels and epilepsy. Am J Med Genet 106, 146\u2013159 (2001).","journal-title":"Am J Med Genet"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1471-4159.2000.0750028.x","article-title":"Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability","volume":"75","author":"Watanabe H","year":"2000","unstructured":"H Watanabe, , Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J Neurochem 75, 28\u201333 (2000).","journal-title":"J Neurochem"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2174\/138161280504230110100800","article-title":"Cognition enhancement strategies by ion channel modulation of neurotransmission","volume":"5","author":"Eid CN","year":"1999","unstructured":"Jr CN Eid, GM Rose, Cognition enhancement strategies by ion channel modulation of neurotransmission. Curr Pharm Des 5, 345\u2013361 (1999).","journal-title":"Curr Pharm Des"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/0975-3583.89811","article-title":"Acute ST-segment elevation myocardial infarction from a centipede bite","volume":"2","author":"Senthilkumaran S","year":"2011","unstructured":"S Senthilkumaran, R Meenakshisundaram, AD Michaels, P Suresh, P Thirumalaikolundusubramanian, Acute ST-segment elevation myocardial infarction from a centipede bite. J Cardiovasc Dis Res 2, 244\u2013246 (2011).","journal-title":"J Cardiovasc Dis Res"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1021\/pr300881d","article-title":"Venomic and transcriptomic analysis of centipede Scolopendra subspinipes dehaani","volume":"11","author":"Liu ZC","year":"2012","unstructured":"ZC Liu, , Venomic and transcriptomic analysis of centipede Scolopendra subspinipes dehaani. J Proteome Res 11, 6197\u20136212 (2012).","journal-title":"J Proteome Res"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1714760115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1714760115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T13:09:35Z","timestamp":1693487375000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1714760115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,2,13]]}},"alternative-id":["10.1073\/pnas.1714760115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1714760115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]},"assertion":[{"value":"2018-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}