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The\n                    <jats:italic>RB1<\/jats:italic>\n                    gene product, pRB, associates with the RBP2 histone demethylase and RBP2 is deregulated in\n                    <jats:italic>RB1<\/jats:italic>\n                    -null cancers. Here, we show that genetic ablation of RBP2 in established, autochthonous pRB-defective murine tumors retards their growth and enhances mouse survival. Our findings provide a further rationale for the development and testing of pharmacological RBP2 inhibitors for cancer treatment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1716029115","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T16:41:27Z","timestamp":1522687287000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":15,"title":["Autochthonous tumors driven by\n                    <i>Rb1<\/i>\n                    loss have an ongoing requirement for the RBP2 histone demethylase"],"prefix":"10.1073","volume":"115","author":[{"given":"Samuel K.","family":"McBrayer","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Olenchock","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, 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