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Urogenital birth defects account for as many at 30% of structural anomalies, and the 16p11.2 genetic locus is among the most common copy variant regions. Herein is shown that variation in copy number of the transcription factor\n                    <jats:italic>MA<\/jats:italic>\n                    <jats:italic>Z<\/jats:italic>\n                    , located within the 16p11.2 locus, contributes significantly to a wide range of the urogenital birth defects associated with this genomic syndrome, including structural abnormalities of the developing kidneys, ureters, and bladder. Understanding large chromosomal aberrations by studying the functions of individual developmental genes at each variant locus will pave the way for future targeted therapies in affected pregnancies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1716092115","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T10:23:15Z","timestamp":1518517395000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":54,"title":["16p11.2 transcription factor\n                    <i>MAZ<\/i>\n                    is a dosage-sensitive regulator of genitourinary development"],"prefix":"10.1073","volume":"115","author":[{"given":"Meade","family":"Haller","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030;"},{"name":"Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030;"},{"name":"Department of Urology, Baylor 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