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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,4,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Recent clinical studies suggest that environmental insults, such as valproic acid (VPA) exposure, in utero can have adverse effects on brain function of the offspring in later life, although the underlying mechanisms of these impairments remain poorly understood. By focusing on the property of neural stem\/progenitor cells (NS\/PCs) residing in the adult hippocampus, we identified the mechanism of increased seizure sensitivity in prenatally VPA-exposed adult mice. Furthermore, we found that voluntary exercise can overcome the adverse effects through normalizing VPA-induced transcriptome alterations in NS\/PCs. We believe that our study provides insights for further understanding and developing treatment strategies for neurological disorders induced by prenatal environmental insults.<\/jats:p>","DOI":"10.1073\/pnas.1716479115","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T16:43:51Z","timestamp":1522687431000},"page":"4270-4275","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice"],"prefix":"10.1073","volume":"115","author":[{"given":"Atsuhiko","family":"Sakai","sequence":"first","affiliation":[{"name":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan;"},{"name":"Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taito","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nagaishi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-9628","authenticated-orcid":false,"given":"Kinichi","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(11)70107-7","article-title":"Dose-dependent risk of malformations with antiepileptic drugs: An analysis of data from the EURAP epilepsy and pregnancy registry","volume":"10","author":"Tomson T","year":"2011","unstructured":"T Tomson, , Dose-dependent risk of malformations with antiepileptic drugs: An analysis of data from the EURAP epilepsy and pregnancy registry. 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