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Although HD is classically considered a motor disorder, HD patients experience learning and memory deficits years before the onset of motor symptoms, and these deficits resemble those observed in HD mouse models. In this work, using transgenic mouse models of HD, we demonstrate that the action of the neurotransmitter GABA has switched from inhibitory to excitatory. By treating HD mice with a clinically used diuretic (bumetanide), which restores inhibitory GABA, we rescued the learning and memory deficits. Our data suggest a potential therapeutic approach for the treatment of the cognitive deficits in early HD that can improve patient quality of life and reduce caregiver burden.<\/jats:p>","DOI":"10.1073\/pnas.1716871115","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T12:02:08Z","timestamp":1517313728000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["Restoring GABAergic inhibition rescues memory deficits in a Huntington\u2019s disease mouse model"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-2034","authenticated-orcid":false,"given":"Zahra","family":"Dargaei","sequence":"first","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Yoon","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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