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The interaction involves unusual, transient, electrostatic interactions between the short fiber capsid protein and polysialic acid (polySia)-containing receptors on target cells. Knowledge about the binding interactions between polySia and its natural ligands is relatively limited, and our results therefore provide additional insight not only into adenovirus biology but also into the structural basis of polySia function. Since polySia can be found in high expression levels in brain and lung cancers where its presence is associated with poor prognosis, we suggest that this polySia-binding adenovirus could be useful for design of vectors for gene therapy of these cancers.<\/jats:p>","DOI":"10.1073\/pnas.1716900115","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T15:35:49Z","timestamp":1524152149000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["Polysialic acid is a cellular receptor for human adenovirus 52"],"prefix":"10.1073","volume":"115","author":[{"given":"Annasara","family":"Lenman","sequence":"first","affiliation":[{"name":"Division of Virology, Department of Clinical Microbiology, and Laboratory for Molecular Infection Medicine Sweden, Ume\u00e5 University, SE-90185 Ume\u00e5, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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