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U.S.A."],"published-print":{"date-parts":[[2017,12,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    A family of adaptor protein (AP) complexes functions to sort transmembrane cargos at different stages of the endomembrane system of eukaryotic cells. AP-4 is one of the most recently described and least well-understood members of this family. Interest in this complex has risen because mutations in any of its four subunits cause a form of hereditary spastic paraplegia (HSP) with intellectual disability. In this study, we demonstrate that AP-4 sorts ATG9A, the only transmembrane component of the core autophagy machinery, from the\n                    <jats:italic>trans<\/jats:italic>\n                    -Golgi network to peripheral compartments. This sorting is required to promote the early steps of autophagosome formation. Our observations implicate AP-4 as an autophagy regulator and altered autophagy as an underlying defect in AP-4\u2013deficient HSP.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1717327114","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T15:02:43Z","timestamp":1511794963000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":179,"title":["AP-4 mediates export of ATG9A from the\n                    <i>trans<\/i>\n                    -Golgi network to promote autophagosome formation"],"prefix":"10.1073","volume":"114","author":[{"given":"Rafael","family":"Mattera","sequence":"first","affiliation":[{"name":"Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Yoon","family":"Park","sequence":"additional","affiliation":[{"name":"Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"De Pace","sequence":"additional","affiliation":[{"name":"Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Guardia","sequence":"additional","affiliation":[{"name":"Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan S.","family":"Bonifacino","sequence":"additional","affiliation":[{"name":"Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01079-1"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20140069"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.04.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.7278"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.8.2787"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.31083"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.9.4933"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.5.917"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.22.6265"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201111049"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.683409"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12375"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.01.015"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208635109"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088147"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12465"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.02.012"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00164-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.082263"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.004"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.019"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150400"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.034"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00402-7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03172"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-09-0746"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1242\/jcs.196196","article-title":"Atg9A trafficking through the recycling endosomes is required for autophagosome formation","volume":"129","author":"Imai K","year":"2016","unstructured":"K Imai, , Atg9A trafficking through the recycling endosomes is required for autophagosome formation. 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