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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    N6-methyladnosine (m6A) represents one of the most common RNA modifications. Biochemical analyses have identified ALKBH5 as an eraser of m6A. The present study represents the first molecular characterization of the\n                    <jats:italic>Alkbh5<\/jats:italic>\n                    knockout mouse model. Our data associate m6A erasure with mRNA length control. Specifically, proper m6A demethylation is required for correct splicing and selective degradation of longer 3\u2032-UTR transcripts, which are abundant in mitotic and meiotic male germ cells, but these longer 3\u2032-UTR transcripts become rapidly degraded in the haploid male germ cells. Aberrant m6A levels in spermatogenic cells are incompatible with normal spermatogenesis and male fertility.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1717794115","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T12:56:57Z","timestamp":1514293017000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":453,"title":["ALKBH5-dependent m6A demethylation controls splicing and stability of long 3\u2032-UTR mRNAs in male germ cells"],"prefix":"10.1073","volume":"115","author":[{"given":"Chong","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Klukovich","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Klungland","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway;"},{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"},{"name":"Department of Biology, University of Nevada, Reno, Reno, NV 89557"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,12,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nchembio.482","article-title":"Grand challenge commentary: RNA epigenetics?","volume":"6","author":"He C","year":"2010","unstructured":"C He, Grand challenge commentary: RNA epigenetics? 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