{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:30:09Z","timestamp":1790634609047,"version":"4.1.0"},"reference-count":57,"publisher":"National Academy of Sciences","issue":"5","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA057621"],"award-info":[{"award-number":["R01 CA057621"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA180039"],"award-info":[{"award-number":["R01 CA180039"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA199315"],"award-info":[{"award-number":["U01 CA199315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009035","name":"Academic Senate, University of California, Riverside","doi-asserted-by":"publisher","award":["34935\/500394"],"award-info":[{"award-number":["34935\/500394"]}],"id":[{"id":"10.13039\/100009035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["R10081HS"],"award-info":[{"award-number":["R10081HS"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["C14007HS"],"award-info":[{"award-number":["C14007HS"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["R10081HS"],"award-info":[{"award-number":["R10081HS"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["C14007HS"],"award-info":[{"award-number":["C14007HS"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,1,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Previous work showed that primary tumors instigate systemic macroenvironmental changes supporting cancer progression and metastasis. Here, we show that activation of HIF signaling in osteoblast-lineage cells also generates systemic changes promoting breast cancer growth and dissemination in bones and outside the skeleton. Our results indicate that loss of bone homeostasis through alterations of the bone anabolism could affect breast cancer progression and present the skeleton as an important organ of the tumor macroenvironment. They also suggest that targeting the bone microenvironment could limit systemic tumor growth and dissemination in breast cancer.<\/jats:p>","DOI":"10.1073\/pnas.1718009115","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T11:42:46Z","timestamp":1516102966000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":82,"title":["HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice"],"prefix":"10.1073","volume":"115","author":[{"given":"Claire-Sophie","family":"Devignes","sequence":"first","affiliation":[{"name":"INSERM U1132, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetki","family":"Aslan","sequence":"additional","affiliation":[{"name":"INSERM U1132, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Brenot","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Devillers","sequence":"additional","affiliation":[{"name":"INSERM U1132, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Schepers","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300RC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Fabre","sequence":"additional","affiliation":[{"name":"INSERM U1132, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy-Jo","family":"Casbon","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zena","family":"Werb","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Provot","sequence":"additional","affiliation":[{"name":"INSERM U1132, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04524"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.07.015"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.11.017"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012370544-0.50012-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.07.010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.03.013"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11926"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.047"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.042"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.08.050"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.139"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.01.002"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.051"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22396"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31581"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.021"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3330"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14492"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006896"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63568-7"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02480"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.11.3005"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1583"},{"key":"e_1_3_3_26_2","first-page":"3569","article-title":"HER-2\/neu is a tumor rejection target in tolerized HER-2\/neu transgenic mice","volume":"60","author":"Reilly RT","year":"2000","unstructured":"RT Reilly, , HER-2\/neu is a tumor rejection target in tolerized HER-2\/neu transgenic mice. Cancer Res 60, 3569\u20133576 (2000).","journal-title":"Cancer Res"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2448"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0896(96)00042-9"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1075"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.034"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10520"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.053"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.10.004"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2819"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.053389"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.043"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.07.008"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08851"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00301"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002562"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0190-7"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00301-2"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540170048031"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23674"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070980"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2006.09.005"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2011.557754"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2013.11.009"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116515"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01831380"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12072"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199702273360903"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0078-2"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1189"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608382104"},{"key":"e_1_3_3_56_2","first-page":"6876","article-title":"A murine model of experimental metastasis to bone and bone marrow","volume":"48","author":"Arguello F","year":"1988","unstructured":"F Arguello, RB Baggs, CN Frantz, A murine model of experimental metastasis to bone and bone marrow. Cancer Res 48, 6876\u20136881 (1988).","journal-title":"Cancer Res"},{"key":"e_1_3_3_57_2","article-title":"Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth","volume":"96","author":"Kocat\u00fcrk B","year":"2015","unstructured":"B Kocat\u00fcrk, HH Versteeg, Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth. J Vis Exp 96\u2013e51967 (2015).","journal-title":"J Vis Exp"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1718009115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1718009115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:52:54Z","timestamp":1649818374000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1718009115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,1,30]]}},"alternative-id":["10.1073\/pnas.1718009115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1718009115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]},"assertion":[{"value":"2018-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}