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Our study thus provides a remarkable example for compound class discovery and for the adaptability of GPCRs to chemically diverse ligands.<\/jats:p>","DOI":"10.1073\/pnas.1718084115","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T15:17:58Z","timestamp":1521472678000},"page":"3640-3645","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["Ligand channel in pharmacologically stabilized rhodopsin"],"prefix":"10.1073","volume":"115","author":[{"given":"Daniel","family":"Mattle","sequence":"first","affiliation":[{"name":"Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland;"},{"name":"Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Aebi","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. 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X.","family":"Schertler","sequence":"additional","affiliation":[{"name":"Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland;"},{"name":"Department of Biology, ETH Zurich, 8093 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hennig","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Standfuss","sequence":"additional","affiliation":[{"name":"Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-5883","authenticated-orcid":false,"given":"Roger J. 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