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Our findings help explain why single channel-blocker therapy may fail, and highlight the need to understand the integrated changes of ionic currents in treating arrhythmias in HF.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1718211115","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T15:43:41Z","timestamp":1520869421000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":93,"title":["Complex electrophysiological remodeling in postinfarction ischemic heart failure"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-221X","authenticated-orcid":false,"given":"Bence","family":"Hegyi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh G.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, University of California, Davis, CA 95616;"},{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55902;"},{"name":"College of Medicine, Mayo Clinic, Rochester, MN 55902;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Shimkunas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"},{"name":"Department of Biomedical Engineering, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zana","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin N.","family":"Grimsrud","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Davis, Sacramento, CA 95817;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus S.","family":"Sondergaard","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Davis, Sacramento, CA 95817;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipavan","family":"Chiamvimonvat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616;"},{"name":"Department of Veterans Affairs, Northern California Health Care System, Mather, CA 95655;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Belardinelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Gilead Sciences, Inc., Foster City, CA 94404;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Varr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary;"},{"name":"MTA-SZTE Research Group of Cardiovascular Pharmacology, Hungarian Academy of Sciences, H-6720 Szeged, Hungary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius G.","family":"Papp","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary;"},{"name":"MTA-SZTE Research Group of Cardiovascular Pharmacology, Hungarian Academy of Sciences, H-6720 Szeged, Hungary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Pollesello","sequence":"additional","affiliation":[{"name":"Critical Care Proprietary Products, Orion Pharma, FI-02200 Espoo, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko","family":"Levijoki","sequence":"additional","affiliation":[{"name":"Critical Care Proprietary Products, Orion Pharma, FI-02200 Espoo, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leighton T.","family":"Izu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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