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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,3,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Middle East respiratory syndrome (MERS) is a zoonotic disease of global health concern, and dromedary camels are the source of human infection. Although Africa has the largest number of dromedary camels, and MERS-coronavirus (MERS-CoV) is endemic in these camels, locally acquired zoonotic MERS is not reported from Africa. However, little is known of the genetic or phenotypic characterization of MERS-CoV from Africa. In this study we characterize MERS-CoV from Burkina Faso, Nigeria, Morocco, and Ethiopia. We demonstrate viral genetic and phenotypic differences in viruses from West Africa, which may be relevant to differences in zoonotic potential, highlighting the need for studies of MERS-CoV at the animal\u2013human interface.<\/jats:p>","DOI":"10.1073\/pnas.1718769115","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T16:06:39Z","timestamp":1520265999000},"page":"3144-3149","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":181,"title":["MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity"],"prefix":"10.1073","volume":"115","author":[{"given":"Daniel K. W.","family":"Chu","sequence":"first","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenrie P. Y.","family":"Hui","sequence":"additional","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranawaka A. P. M.","family":"Perera","sequence":"additional","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Miguel","sequence":"additional","affiliation":[{"name":"Animal, Sant\u00e9, Territoires, Risques et Ecosyst\u00e8mes, Centre de Coop\u00e9ration Internationale en Recherche Agronomique pour le D\u00e9veloppement, Institut National de la Recherche Agronomique, Universit\u00e9 de Montpellier, F-34398 Montpellier, France;"},{"name":"Maladies Infectieuses et Vecteurs: Ecologie, G\u00e9n\u00e9tique, Evolution et Contr\u00f4le, L'Institut de Recherche pour le D\u00e9veloppement, CNRS, Universit\u00e8 de Montpellier, F-34398 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Institute of Virology, Campus Charite Mitte, Charite-Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242;"},{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, Republic of China 510000;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudragouda","family":"Channappanavar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gytis","family":"Dudas","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamiu O.","family":"Oladipo","sequence":"additional","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China;"},{"name":"Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie et Sant\u00e9 Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso\/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04, Burkina Faso;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouafaa","family":"Fassi-Fihri","sequence":"additional","affiliation":[{"name":"Institut Agronomique et V\u00e9t\u00e9rinaire, Hassan II Universit\u00e9, B.P. 6202 Rabat-Instituts, Rabat, Morocco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Ali","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getnet F.","family":"Demissi\u00e9","sequence":"additional","affiliation":[{"name":"College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Muth","sequence":"additional","affiliation":[{"name":"Institute of Virology, Campus Charite Mitte, Charite-Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C. 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