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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,3,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Measles remains a major cause of childhood morbidity and mortality worldwide, and no licensed therapeutic agents are currently available. Measles virus (MeV) sometimes invades the central nervous system (CNS), causing neurodegenerative diseases several months\/years after acute infection. Recently, MeV-induced encephalitis among human immunodeficiency virus (HIV)-infected children has become a great concern in high\u2013HIV-prevalence countries. The tropism of MeV for the CNS is mediated by hyperfusogenic mutations in the MeV fusion (F) protein. Here we show the crystal structures of MeV-F alone and bound to inhibitors. The structures and accompanying cell-based fusion assays with inhibitors provide insight into the molecular mechanism for the inhibition of MeV-mediated fusion, which would help us conquer MeV-induced neurodegenerative diseases.<\/jats:p>","DOI":"10.1073\/pnas.1718957115","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T14:34:52Z","timestamp":1519137292000},"page":"2496-2501","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["Structures of the prefusion form of measles virus fusion protein in complex with inhibitors"],"prefix":"10.1073","volume":"115","author":[{"given":"Takao","family":"Hashiguchi","sequence":"first","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 812-8582 Fukuoka, Japan;"},{"name":"Biostructural Mechanism Laboratory, RIKEN SPring-8 Center, 679-5148 Hyogo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-4785","authenticated-orcid":false,"given":"Daisuke","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Engineering, The University of Tokyo, 113-8656 Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Shirogane","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Tsumoto","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Engineering, The University of Tokyo, 113-8656 Tokyo, Japan;"},{"name":"Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, 108-8639 Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kohda","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Karl","family":"Plemper","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, 812-8582 Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"1042","volume-title":"Fields Virology","author":"Griffin DE","year":"2013","unstructured":"DE Griffin, Measles virus. 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J Infect Dis 192, 1686\u20131693 (2005).","journal-title":"J Infect Dis"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00430-010-0153-2","article-title":"Measles virus infection of the CNS: Human disease, animal models, and approaches to therapy","volume":"199","author":"Reuter D","year":"2010","unstructured":"D Reuter, J Schneider-Schaulies, Measles virus infection of the CNS: Human disease, animal models, and approaches to therapy. Med Microbiol Immunol (Berl) 199, 261\u2013271 (2010).","journal-title":"Med Microbiol Immunol (Berl)"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/35022579","article-title":"SLAM (CDw150) is a cellular receptor for measles virus","volume":"406","author":"Tatsuo H","year":"2000","unstructured":"H Tatsuo, N Ono, K Tanaka, Y Yanagi, SLAM (CDw150) is a cellular receptor for measles virus. 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