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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>B lymphocytes change the type of antibody they express to combat infections though a DNA breakage and joining process termed antibody class switch recombination (CSR). During CSR, DNA breaks are introduced into two specific regions of the antibody locus, and these two DNA breaks are joined to make the new form of the antibody gene. Like other genomic breaks, CSR DNA breaks activate a cellular DNA damage response pathway that helps ensure their proper repair. We now show that, when certain components of the DNA damage response pathway are inactivated, B-cell CSR junctions show different molecular signatures, indicating that they are repaired by a less-efficient alternative DNA repair pathway instead of the normal general cellular DNA break repair pathway.<\/jats:p>","DOI":"10.1073\/pnas.1719988115","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T15:37:24Z","timestamp":1515425844000},"page":"762-767","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions"],"prefix":"10.1073","volume":"115","author":[{"given":"Rohit A.","family":"Panchakshari","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Kumar","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Du","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chi","family":"Wei","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kao","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Dong","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Alt","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cell.2013.01.007","article-title":"Mechanisms of programmed DNA lesions and genomic instability in the immune system","volume":"152","author":"Alt FW","year":"2013","unstructured":"FW Alt, Y Zhang, FL Meng, C Guo, B Schwer, Mechanisms of programmed DNA lesions and genomic instability in the immune system. 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