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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,4,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Voltage-gated ion channels contain domains that have discrete functionalities. The central pore domain allows current flow and provides ion selectivity, whereas peripherally located voltage-sensing domains (VSDs) are needed for voltage-dependent gating. Certain mutations trigger a leak current through VSDs, known as gating pore current. Hypokalemic periodic paralysis (HypoPP) type 2 is caused by mutations in the skeletal muscle voltage-gated sodium channel Na\n                    <jats:sub>V<\/jats:sub>\n                    1.4 that neutralize positive charges in S4 voltage-sensing segments of VSDs. We show that Hm-3 toxin from the crab spider\n                    <jats:italic>Heriaeus melloteei<\/jats:italic>\n                    inhibits gating pore currents through such mutant channels. We propose that Hm-3 and similar toxins may constitute useful hits in developing gating pore current inhibitors and HypoPP therapy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1720185115","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T11:50:31Z","timestamp":1523361031000},"page":"4495-4500","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":27,"title":["Spider toxin inhibits gating pore currents underlying periodic paralysis"],"prefix":"10.1073","volume":"115","author":[{"given":"Roope","family":"M\u00e4nnikk\u00f6","sequence":"first","affiliation":[{"name":"MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, WC1N 3BG London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakhar O.","family":"Shenkarev","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic 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Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Kuzmin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, WC1N 3BG London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Sampedro Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, WC1N 3BG London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"King","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, WC1N 3BG London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma R.","family":"Wilson","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuromuscular 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