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U.S.A."],"published-print":{"date-parts":[[2018,11,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Substance-use disorders damage individuals and communities, providing large societal costs. For stimulant-use disorders, there are no Food and Drug Administration-approved medications. Human genetic associations with common variants in the gene encoding the receptor-type protein tyrosine phosphatase D (PTPRD) make this cell-adhesion molecule\/synaptic specifier gene an interesting target for new addiction therapeutic agents. We now report results of cocaine self-administration in heterozygous PTPRD-KO mice, discovery that 7-butoxy illudalic acid analog (7-BIA) inhibits PTPRD\u2019s phosphatase with in vitro potency and specificity, and discovery that 7-BIA reduces cocaine reward in self-administration and conditioned place-preference models. 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