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U.S.A."],"published-print":{"date-parts":[[2018,4,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    RNAs contain over 100 types of chemical modifications, and\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) is the most common internal modification in eukaryotic mRNA. m\n                    <jats:sup>6<\/jats:sup>\n                    A is involved in a variety of important biological processes, including sex determination in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , by modifying\n                    <jats:italic>Sxl<\/jats:italic>\n                    pre-mRNA and regulating its alternative splicing. m\n                    <jats:sup>6<\/jats:sup>\n                    A is installed by a large methyltransferase complex called the m\n                    <jats:sup>6<\/jats:sup>\n                    A \u201cwriter.\u201d We have identified\n                    <jats:italic>xio<\/jats:italic>\n                    as a component of the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    sex determination pathway based on its female-to-male transformation phenotypes. Xio interacts with other m\n                    <jats:sup>6<\/jats:sup>\n                    A writer subunits, and its loss of function shows typical phenotypes associated with other m\n                    <jats:sup>6<\/jats:sup>\n                    A factors, such as\n                    <jats:italic>Sxl<\/jats:italic>\n                    splicing misregulation, adult defects, and reduced m\n                    <jats:sup>6<\/jats:sup>\n                    A levels. Therefore, we conclude that Xio is a member of the m\n                    <jats:sup>6<\/jats:sup>\n                    A writer complex.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1720945115","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T15:16:37Z","timestamp":1521472597000},"page":"3674-3679","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":100,"title":["Xio is a component of the\n                    <i>Drosophila<\/i>\n                    sex determination pathway and RNA\n                    <i>N<\/i>\n                    <sup>6<\/sup>\n                    -methyladenosine methyltransferase complex"],"prefix":"10.1073","volume":"115","author":[{"given":"Jian","family":"Guo","sequence":"first","affiliation":[{"name":"Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China;"},{"name":"University of Chinese Academy of Sciences, 100049 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Wen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China;"},{"name":"University of Chinese Academy of Sciences, 100049 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Perrimon","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"},{"name":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Insect Developmental and Evolutionary Biology, Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1146\/annurev.genet.30.1.637","article-title":"Vive la diff\u00e9rence: Males vs females in flies vs worms","volume":"30","author":"Cline TW","year":"1996","unstructured":"TW Cline, BJ Meyer, Vive la diff\u00e9rence: Males vs females in flies vs worms. 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