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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,8,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The role of metabolic processes during T cell activation has been increasingly acknowledged, and recent data suggest an impact of T cell immunometabolism on T cell function and T cell-mediated autoimmunity. The factors regulating metabolic function in T cells are not clear, however. We identify the nuclear receptor Nur77 as central regulator of T cell immunometabolism, controlling oxidative phosphorylation and aerobic glycolysis during T cell activation. Functionally, Nur77 restricts murine and human T cell activation and proliferation and limits inflammation in autoimmune conditions in animal models of CNS autoimmunity, contact dermatitis, and arthritis. These findings identify Nur77 as a central regulator of T cell immunometabolism that restricts T cell-mediated autoimmunity, which might open up new avenues for a more tailored therapeutic approach.<\/jats:p>","DOI":"10.1073\/pnas.1721049115","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T17:15:03Z","timestamp":1533230103000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity"],"prefix":"10.1073","volume":"115","author":[{"given":"Marie","family":"Liebmann","sequence":"first","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, 48149 Muenster, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Hucke","sequence":"additional","affiliation":[{"name":"Department of 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