{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:53:34Z","timestamp":1791320014335,"version":"4.3.1"},"reference-count":54,"publisher":"National Academy of Sciences","issue":"30","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,7,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Our data suggest opposite roles for ROCK1 and ROCK2 in cardiomyocytes. Additional studies identified downstream targets of ROCK1 and ROCK2 related to calcium handling, mitochondrial function, and oxidative stress. In particular, our findings indicate that cyclophilin A (CyPA) and basigin (Bsg), both of which augment oxidative stress, enhanced cardiac dysfunction and postcapillary pulmonary hypertension (PH) in\n                    <jats:italic>cROCK1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, while their expressions were lower in\n                    <jats:italic>cROCK2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Finally, screening of the public chemical library in the Drug Discovery Initiative enabled us to identify compounds that reduce the expressions of CyPA and Bsg. Among them, celastrol suppressed the expression of both CyPA and Bsg in heart and lungs, thereby ameliorating both heart failure and postcapillary PH in mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1721298115","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T15:16:33Z","timestamp":1531149393000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":84,"title":["Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice"],"prefix":"10.1073","volume":"115","author":[{"given":"Shinichiro","family":"Sunamura","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimio","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kurosawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ohtsuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Elias-Al-Mamun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taijyu","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Nogi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Numano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Abdul Hai","family":"Siddique","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.067"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.057"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.302929"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048064"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.033"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.10.021"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01102-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018935"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.049"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305353"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306532"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.11.1319"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/40187"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301357"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303320"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc1002.105938"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31816533b7"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0443"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0433"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-217018"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5129com"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000162457.56568.7d"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1247\/csf.16011"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301651"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.907717"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306686"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.008"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303356"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.214601"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.304563"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.085761"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00069"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601911103"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93187"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000096650.91688.28"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx103"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002178107"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.2.504"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.03.018"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.09.019"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101174"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1958"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.235.1"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254415.31362.a7"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309212"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305872"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.19"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414189111"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102863"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0355OC"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.09.033"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1721298115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T03:47:06Z","timestamp":1649821626000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1721298115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":54,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2018,7,24]]}},"alternative-id":["10.1073\/pnas.1721298115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1721298115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,9]]},"assertion":[{"value":"2018-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}