{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:02:28Z","timestamp":1790712148267,"version":"4.1.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"25","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,6,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    BP180 is a cell\u2013cell matrix adhesion molecule and is critical for attachment of epidermis to underlying dermis. We generated a dysfunctional BP180 mouse strain (\u0394\n                    <jats:italic>NC16A<\/jats:italic>\n                    mice). The \u0394\n                    <jats:italic>NC16A<\/jats:italic>\n                    mice at 8 weeks start developing spontaneous itch and skin inflammation characterized by increased skin thickness, infiltrating immune cells, increased levels of IgE in circulation, proinflammatory mediators in the skin, and impaired skin barrier. Bullous pemphigoid (BP) patients also present increased TSLP in lesional skin and circulation. Our findings suggest that BP180 regulates pruritic skin inflammation. Elucidation of molecular and cellular mechanisms underlying the role of BP180 in skin inflammation should help better understanding of pathophysiology of skin inflammation and identify therapeutic targets for skin inflammatory diseases such as BP and atopic dermatitis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1721805115","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T15:05:13Z","timestamp":1528124713000},"page":"6434-6439","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["BP180 dysfunction triggers spontaneous skin inflammation in mice"],"prefix":"10.1073","volume":"115","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, 710004 Shaanxi, China;"},{"name":"Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-Jin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;"},{"name":"Guangdong Center for Adverse Drug Reactions of Monitoring, 510000 Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Lough","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;"},{"name":"Wuhan No. 1 Hospital, The Fourth Affiliated Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, 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