{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:12:07Z","timestamp":1790417527614,"version":"4.1.0"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"35","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA31534"],"award-info":[{"award-number":["R01CA31534"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP120348 and RP120459"],"award-info":[{"award-number":["RP120348 and RP120459"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","award":["300463"],"award-info":[{"award-number":["300463"]}],"id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Major Founamental Research Program of China","award":["2014CB942902"],"award-info":[{"award-number":["2014CB942902"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91749103"],"award-info":[{"award-number":["91749103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81421061"],"award-info":[{"award-number":["81421061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31100624 and 81200586"],"award-info":[{"award-number":["31100624 and 81200586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Comprehensive Strategic Cooperation between Guangdong Province and Chinese Acadamy of Sciences","award":["2012B091100260"],"award-info":[{"award-number":["2012B091100260"]}]},{"name":"Guangdong Acadamy of Sciences","award":["2016GDASPT-0215; 2017GDASCX-0107"],"award-info":[{"award-number":["2016GDASPT-0215; 2017GDASCX-0107"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,8,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Speech and bipedalism are key aspects of behavior that emerged during human evolution.\n                    <jats:italic>FOXP2<\/jats:italic>\n                    , a gene implicated in a human speech and language disorder, has been suggested to contribute to language evolution. Here, through knockout studies of mouse\n                    <jats:italic>Foxp2<\/jats:italic>\n                    , we show that this gene is not only important for neural circuits involved in vocal behaviors, it also helps regulate relevant anatomical substrates. We additionally demonstrate that\n                    <jats:italic>Foxp2<\/jats:italic>\n                    influences skeletal features that may be relevant for bipedal locomotion. Our findings raise the possibility that\n                    <jats:italic>FOXP2<\/jats:italic>\n                    might be important for anatomical features contributing to derived human traits, including speech and bipedalism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1721820115","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T15:16:56Z","timestamp":1534173416000},"page":"8799-8804","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion"],"prefix":"10.1073","volume":"115","author":[{"given":"Shuqin","family":"Xu","sequence":"first","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Liu","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxing","family":"Chen","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, 510260 Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Cao","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Jiang","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojie","family":"Li","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Sixth People\u2019s Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanying","family":"Wei","sequence":"additional","affiliation":[{"name":"The Sixth People\u2019s Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fan","sequence":"additional","affiliation":[{"name":"The Sixth People\u2019s Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"He","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-3529","authenticated-orcid":false,"given":"Joseph D.","family":"Dekker","sequence":"additional","affiliation":[{"name":"Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley O.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1996","authenticated-orcid":false,"given":"Simon E.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands;"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6500 HE, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengju","family":"Yao","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quansheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, 510260 Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechun","family":"Xia","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhi","family":"Guo","sequence":"additional","affiliation":[{"name":"Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00291"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aao5961"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2017.07.002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.930"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf058"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35097076"},{"key":"e_1_3_3_7_2","unstructured":"A Morgan SE Fisher I Scheffer M Hildebrand FOXP2 -related speech and language disorders. Available at https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27336128. Accessed July 26 2018. (2016)."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2009.03.012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.96"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv495"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23303"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36055"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-104094"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-016-9177-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033130"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503739102"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712298105"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.02.062"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12274"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00197"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90415.2008"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00607.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.021"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01025"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msn091"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.03.041"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414542111"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.03.030"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08549"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.12.007"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4380"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.022440799"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01494-7"},{"key":"e_1_3_3_34_2","first-page":"103","article-title":"Evo-devo insights from pathological networks: Exploring craniosynostosis as a developmental mechanism for modularity and complexity in the human skull","volume":"93","author":"Esteve-Altava B","year":"2015","unstructured":"B Esteve-Altava, D Rasskin-Gutman, Evo-devo insights from pathological networks: Exploring craniosynostosis as a developmental mechanism for modularity and complexity in the human skull. J Anthropol Sci 93, 103\u2013117 (2015).","journal-title":"J Anthropol Sci"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03052"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89511"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.039"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.03.002"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1605"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.105"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002145"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.01.060"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.11.027"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1086\/508902"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34354"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050321"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.08.032"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9978"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00478.2011"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.07.003"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.167"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.305037.117"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx055"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715120115"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/30227"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1721820115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1721820115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T03:47:00Z","timestamp":1649821620000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1721820115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,13]]},"references-count":55,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2018,8,28]]}},"alternative-id":["10.1073\/pnas.1721820115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1721820115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,13]]},"assertion":[{"value":"2018-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}