{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:29:22Z","timestamp":1781108962980,"version":"3.54.1"},"reference-count":53,"publisher":"National Academy of Sciences","issue":"11","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,3,13]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The discovery of\n                    <jats:italic>MLH1<\/jats:italic>\n                    -rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques (\n                    <jats:italic>MLH1<\/jats:italic>\n                    -rheMac HNPCC), which is an orthologue of Lynch syndrome in humans, is highly significant in the field of oncology. The hereditary nature of this disease should allow for planned cross-breeding of rhesus macaques to assess the effects of homozygous versus heterozygous\n                    <jats:italic>MLH1<\/jats:italic>\n                    gene mutations, as well as other comutations and environmental factors that may affect the development of colon cancers. Also, the\n                    <jats:italic>MLH1<\/jats:italic>\n                    -rheMac HNPCC syndrome in rhesus macaques can serve as an important model for development of novel approaches to diagnosis and therapy of Lynch syndrome in human patients.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1722106115","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T15:10:31Z","timestamp":1519830631000},"page":"2806-2811","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques"],"prefix":"10.1073","volume":"115","author":[{"given":"David W.","family":"Brammer","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthuswamy","family":"Raveendran","sequence":"additional","affiliation":[{"name":"Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence E.","family":"Williams","sequence":"additional","affiliation":[{"name":"Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Gagea","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J.","family":"Benavides","sequence":"additional","affiliation":[{"name":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Smithville, TX 78957;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell R.","family":"Broaddus","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Bernacky","sequence":"additional","affiliation":[{"name":"Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin F.","family":"Barnhart","sequence":"additional","affiliation":[{"name":"Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian M.","family":"Alauddin","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoop S.","family":"Bhutani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Sidman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey at University Hospital, Newark, NJ 07103;"},{"name":"Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, NJ 07103;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wadih","family":"Arap","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey at University Hospital, Newark, NJ 07103;"},{"name":"Division of Hematology\/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Rogers","sequence":"additional","affiliation":[{"name":"Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Abee","sequence":"additional","affiliation":[{"name":"Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juri G.","family":"Gelovani","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030;"},{"name":"Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI 48201;"},{"name":"Department of Biomedical Engineering, College of Engineering and School of Medicine, Wayne State University, Detroit, MI 48201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985871008005-00609"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588001700513"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4918-4_53"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2345(1998)44:1<19::AID-AJP2>3.0.CO;2-#"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3311"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1998.tb00082.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1996.tb00040.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588201907s08"},{"key":"e_1_3_2_9_2","first-page":"40","article-title":"Metastatic large intestinal adenocarcinoma in two rhesus macaques (Macaca mulatta)","volume":"39","author":"Kerrick GP","year":"2000","unstructured":"GP Kerrick, DG Brownstein, Metastatic large intestinal adenocarcinoma in two rhesus macaques (Macaca mulatta). Contemp Top Lab Anim Sci 39, 40\u201342 (2000).","journal-title":"Contemp Top Lab Anim Sci"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1997.tb00216.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2000.0435"},{"key":"e_1_3_2_12_2","first-page":"540","article-title":"Spontaneous intestinal adenocarcinoma in geriatric macaques (Macaca sp.)","volume":"50","author":"Valverde CR","year":"2000","unstructured":"CR Valverde, RP Tarara, SM Griffey, JA Roberts, Spontaneous intestinal adenocarcinoma in geriatric macaques (Macaca sp.). Comp Med 50, 540\u2013544 (2000).","journal-title":"Comp Med"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-011-0485-3"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.086777"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1966.03870080050009"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01230.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2011.05.003"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27996"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805213382101"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.048991"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/391039"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02053699"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/368258a0"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90546-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90330-S"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128251"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/371075a0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/305058"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1193-279"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1500.1998.00050.x"},{"key":"e_1_3_2_33_2","first-page":"5248","article-title":"A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland CR","year":"1998","unstructured":"CR Boland, , A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58, 5248\u20135257 (1998).","journal-title":"Cancer Res"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00649-6"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03479.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh940"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139247"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9455-9"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.4.661"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.09.036"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.25"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-007-9104-z"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.t01-1-00110.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk095"},{"key":"e_1_3_2_45_2","first-page":"3925","article-title":"A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor","volume":"62","author":"Gazzoli I","year":"2002","unstructured":"I Gazzoli, M Loda, J Garber, S Syngal, RD Kolodner, A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor. Cancer Res 62, 3925\u20133928 (2002).","journal-title":"Cancer Res"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202178"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.6870"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.7329"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24673"},{"key":"e_1_3_2_50_2","volume-title":"Colorectal Cancer: Methods and Protocols","author":"Powell SM","year":"2001","unstructured":", ed SM Powell (Humana Press, Totowa, NJ Colorectal Cancer: Methods and Protocols, 2001)."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2006.08.009"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60611-3"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0010053"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1722106115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T03:12:28Z","timestamp":1649819548000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1722106115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,3,13]]}},"alternative-id":["10.1073\/pnas.1722106115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1722106115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]},"assertion":[{"value":"2018-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}