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Here, we used a murine model of human allergic contact dermatitis to demonstrate a regulatory role of the adaptor mitochondrial antiviral signaling (MAVS) RIG-I\u2013like receptors on disease outcome by modulating gut barrier function and bacterial ecology. Our results highlight an unexpected role of the RIG-I\u2013MAVS pathway in maintenance of intestinal barrier function and modulation of gut commensal flora to prevent the development of inflammatory diseases such as allergy. These data provide a rationale for manipulating the gut microbiota as a therapeutic intervention in subjects at risk of developing allergy.<\/jats:p>","DOI":"10.1073\/pnas.1722372115","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T15:04:30Z","timestamp":1537801470000},"page":"10404-10409","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype"],"prefix":"10.1073","volume":"115","author":[{"given":"Emilie","family":"Plantamura","sequence":"first","affiliation":[{"name":"Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, 69365 Lyon Cedex 07, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiran","family":"Dzutsev","sequence":"additional","affiliation":[{"name":"Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, 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