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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,8,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The human heart is unable to meaningfully recover lost cardiac muscle after injury. As a result, injuries such as myocardial infarction cause irreversible damage that increases the risk for heart failure. Replacing lost or dysfunctional cardiac tissue can potentially reverse or prevent heart failure. Here we demonstrate that experimentally increasing expression of the angiogenic factor\n                    <jats:italic>vegfaa<\/jats:italic>\n                    alone is able to induce a cardiac growth program in zebrafish. We also show evidence that the site of\n                    <jats:italic>vegfaa<\/jats:italic>\n                    expression is important for patterning the cardiac growth response. This work identifies Vegfa as a growth factor capable of activating genetic programs for heart regeneration and has generalizable implications for therapeutic administration of cardiac growth factors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1722594115","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T15:13:41Z","timestamp":1534173221000},"page":"8805-8810","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":84,"title":["Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish"],"prefix":"10.1073","volume":"115","author":[{"given":"Ravi","family":"Karra","sequence":"first","affiliation":[{"name":"Department of Medicine, Duke University Medical Center, Durham, NC 27710;"},{"name":"Regeneration Next, Duke University, Durham, NC 27110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Foglia","sequence":"additional","affiliation":[{"name":"Regeneration Next, Duke University, Durham, NC 27110;"},{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yee","family":"Choi","sequence":"additional","affiliation":[{"name":"Regeneration Next, Duke University, Durham, NC 27110;"},{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Belliveau","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University Medical Center, Durham, NC 27710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"DeBenedittis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University Medical Center, Durham, NC 27710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Poss","sequence":"additional","affiliation":[{"name":"Regeneration Next, Duke University, Durham, NC 27110;"},{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1172\/JCI89786","article-title":"Redirecting cardiac growth mechanisms for therapeutic regeneration","volume":"127","author":"Karra R","year":"2017","unstructured":"R Karra, KD Poss, Redirecting cardiac growth mechanisms for therapeutic regeneration. J Clin Invest 127, 427\u2013436 (2017).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello ER","year":"2011","unstructured":"ER Porrello, , Transient regenerative potential of the neonatal mouse heart. Science 331, 1078\u20131080 (2011).","journal-title":"Science"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss KD","year":"2002","unstructured":"KD Poss, LG Wilson, MT Keating, Heart regeneration in zebrafish. Science 298, 2188\u20132190 (2002).","journal-title":"Science"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","article-title":"Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes","volume":"464","author":"Kikuchi K","year":"2010","unstructured":"K Kikuchi, , Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature 464, 601\u2013605 (2010).","journal-title":"Nature"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling C","year":"2010","unstructured":"C Jopling, , Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 464, 606\u2013609 (2010).","journal-title":"Nature"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2006.08.052","article-title":"A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration","volume":"127","author":"Lepilina A","year":"2006","unstructured":"A Lepilina, , A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127, 607\u2013619 (2006).","journal-title":"Cell"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"13255","DOI":"10.1073\/pnas.1511209112","article-title":"Myocardial NF-\u03baB activation is essential for zebrafish heart regeneration","volume":"112","author":"Karra R","year":"2015","unstructured":"R Karra, AK Knecht, K Kikuchi, KD Poss, Myocardial NF-\u03baB activation is essential for zebrafish heart regeneration. 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