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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Narcolepsy is a chronic neurological disorder that severely affects the day-to-day life and general well-being of the affected individuals. Unfortunately, treatments available to date are symptomatic therapies with an array of adverse effects. Animal studies showed that orexin peptide can be a mechanistic therapy to treat narcolepsy. However, nonpermeability of orexin to brain\u2013blood barrier limits its use in humans. Here we showed that orexin delivered via intrathecal route at the lumbar level significantly inhibited narcoleptic symptoms in mice without altering sleep\/wake profile. Although the outcome of intrathecal treatment may be different in clinical studies, our data indicate the possibility that orexin can be delivered intrathecally in humans, using an implantable, refillable, and programmable miniature pump to treat narcolepsy.<\/jats:p>","DOI":"10.1073\/pnas.1722686115","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T15:15:31Z","timestamp":1526915731000},"page":"6046-6051","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy"],"prefix":"10.1073","volume":"115","author":[{"given":"Mahesh K.","family":"Kaushik","sequence":"first","affiliation":[{"name":"International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, 305-8575 Ibaraki, 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