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Therefore, our studies illuminate a clinical path hypothesis for combining ICB with RNS-reducing agents in the treatment of ICB-resistant cancers.<\/jats:p>","DOI":"10.1073\/pnas.1800695115","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T17:08:09Z","timestamp":1537376889000},"page":"10094-10099","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":150,"title":["Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers"],"prefix":"10.1073","volume":"115","author":[{"given":"Shan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556;"},{"name":"Boler\u2013Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, IN 46556;"},{"name":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556;"},{"name":"Ministry of Education Key Laboratory of Bioinformatics, School of Life Sciences and Tsinghua University\u2013Peking University Joint Center for Life Sciences, Tsinghua University, 100084 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556;"},{"name":"Boler\u2013Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, IN 46556;"},{"name":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556;"},{"name":"Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Bioinformatics, School of Life Sciences and Tsinghua 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University of Notre Dame, Notre Dame, IN 46556;"},{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Gong","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, 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