{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:26:33Z","timestamp":1788215193682,"version":"build-2803163510"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"13","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL059596"],"award-info":[{"award-number":["HL059596"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS072360"],"award-info":[{"award-number":["NS072360"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["No number"],"award-info":[{"award-number":["No number"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK063720"],"award-info":[{"award-number":["DK063720"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,3,27]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Sleep is essential for healthy aging, and most people need approximately 8\u20138-1\/2 hours of sleep per night to feel good and to function optimally. We previously reported a proline-to-arginine mutation in DEC2 that leads to a life-long decrease in daily sleep need. We found that the expression of an important sleep-relevant gene,\n                    <jats:italic>orexin<\/jats:italic>\n                    , was increased in the DEC2 mutant mice. Further investigation revealed that DEC2 is a transcriptional repressor for orexin expression, and that mutant DEC2 exerts less repressor activity than WT-DEC2, resulting in increased orexin expression. This study represents the first step toward understanding the underlying molecular mechanism through which DEC2 modulates sleep.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1801693115","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T15:44:01Z","timestamp":1520869441000},"page":"3434-3439","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["DEC2 modulates orexin expression and regulates sleep"],"prefix":"10.1073","volume":"115","author":[{"given":"Arisa","family":"Hirano","sequence":"first","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ken","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Pt\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"},{"name":"Weill Neuroscience Institute, University of California, San Francisco, CA 94143;"},{"name":"Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA 94143;"},{"name":"Howard Hughes Medical Institute, University of California, San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hui","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA 94143;"},{"name":"Weill Neuroscience Institute, University of California, San Francisco, CA 94143;"},{"name":"Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA 94143;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12371"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1057499"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03453"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.043"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174443"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600039113"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16695"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-405943-6.00010-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01123"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3924"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0748730411419782"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110310"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59489-1.00002-1"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17771"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107962200"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409188200"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210427200"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111652200"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1226339"},{"key":"e_1_3_3_20_2","first-page":"925","article-title":"Transcriptional repression by the basic helix-loop-helix protein Dec2: Multiple mechanisms through E-box elements","volume":"19","author":"Fujimoto K","year":"2007","unstructured":"K Fujimoto, , Transcriptional repression by the basic helix-loop-helix protein Dec2: Multiple mechanisms through E-box elements. 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