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Finally, hippocampus-dependent behavioral analyses, calcium influx assays in hippocampal slices and quantification of dendritic spines demonstrated that low-dose aspirin treatment improved hippocampal plasticity and memory in FAD5X mice, but not in FAD5X\/\n                    <jats:italic>Ppara<\/jats:italic>\n                    -null mice. These findings highlight a property of aspirin: stimulating hippocampal plasticity via direct interaction with PPAR\u03b1.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1802021115","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T15:07:09Z","timestamp":1531753629000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":92,"title":["Aspirin binds to PPAR\u03b1 to stimulate hippocampal plasticity and protect memory"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-1051","authenticated-orcid":false,"given":"Dhruv","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avik","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical 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