{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:35:17Z","timestamp":1788932117322,"version":"build-2803163510"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"24","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["R37 MERIT Award AA11147"],"award-info":[{"award-number":["R37 MERIT Award AA11147"]}]},{"name":"NIH","award":["R01 DE025227"],"award-info":[{"award-number":["R01 DE025227"]}]},{"name":"NIH","award":["P01CA067166"],"award-info":[{"award-number":["P01CA067166"]}]},{"name":"NIH","award":["U10CA180816"],"award-info":[{"award-number":["U10CA180816"]}]},{"name":"NIH","award":["T32 GM089626"],"award-info":[{"award-number":["T32 GM089626"]}]},{"name":"NIH","award":["T32 DK 098132"],"award-info":[{"award-number":["T32 DK 098132"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,6,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Radiation therapy for head and neck cancer often leads to dry mouth, a debilitating condition that affects speaking, swallowing, and other functions related to quality of life. Since salivary functional recovery after radiation is largely dependent on the number of surviving salivary stem\/progenitor cells (SSPCs), we reasoned that protection of SSPCs from injury is critical for mitigating dry mouth. Following radiation, SSPCs accumulate toxic aldehydes that damage DNA, proteins, and lipids, leading to cell death. Here, we identified\n                    <jats:sc>d<\/jats:sc>\n                    -limonene as an activator of aldehyde dehydrogenase 3A1 (ALDH3A1) with a favorable safety profile for clinical use. ALDH3A1 activation decreases aldehyde accumulation in SSPCs, increases sphere-forming ability, reduces apoptosis, and preserves salivary gland structure and function following radiation without reducing the anticancer effects.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1802184115","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T16:30:11Z","timestamp":1527179411000},"page":"6279-6284","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes"],"prefix":"10.1073","volume":"115","author":[{"given":"Julie P.","family":"Saiki","sequence":"first","affiliation":[{"name":"Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 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