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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,6,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    (\n                    <jats:italic>Ct<\/jats:italic>\n                    ) is the most common bacterium responsible for sexually transmitted infections. It constitutes a major public health burden, with the greatest clinical impact occurring in women of reproductive age. A vast proportion of\n                    <jats:italic>Ct<\/jats:italic>\n                    infections are underestimated because they are asymptomatic in nature. This leads to chronic infections with severe consequences, such as ectopic pregnancy, tubal obstruction, infertility, and blindness.\n                    <jats:italic>Ct<\/jats:italic>\n                    is an obligate intracellular pathogen that completes its entire developmental cycle in humans. Here, we demonstrate that galectin-1 (Gal1), an endogenous glycan-binding protein, promotes\n                    <jats:italic>Ct<\/jats:italic>\n                    \u2013host adhesion and invasion. Through glycosylation-dependent mechanisms, Gal1 enhances chlamydial infection by favoring\n                    <jats:italic>Ct<\/jats:italic>\n                    \u2013host cell interactions. Thus, novel therapeutic approaches aimed at disrupting Gal1\u2013\n                    <jats:italic>N<\/jats:italic>\n                    -glycan interactions may reduce the severity of\n                    <jats:italic>Ct<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1802188115","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T15:26:36Z","timestamp":1528730796000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Glycosylation-dependent galectin\u2013receptor interactions promote\n                    <i>Chlamydia trachomatis<\/i>\n                    infection"],"prefix":"10.1073","volume":"115","author":[{"given":"Agustin L.","family":"Lujan","sequence":"first","affiliation":[{"name":"Laboratorio de Fagocitosis, Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"},{"name":"\u00c1rea de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego O.","family":"Croci","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunopatolog\u00eda, Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"},{"name":"Laboratorio de Inmunopatolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, C1428ADN Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n A.","family":"Gambarte Tudela","sequence":"additional","affiliation":[{"name":"Laboratorio de Fagocitosis, Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"},{"name":"\u00c1rea de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella D.","family":"Losinno","sequence":"additional","affiliation":[{"name":"Laboratorio de Fagocitosis, Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"},{"name":"\u00c1rea de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro J.","family":"Cagnoni","sequence":"additional","affiliation":[{"name":"Laboratorio de Glic\u00f3mica Funcional y Molecular, Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, C1428ADN Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina V.","family":"Mari\u00f1o","sequence":"additional","affiliation":[{"name":"Laboratorio de Glic\u00f3mica Funcional y Molecular, Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, C1428ADN Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"Damiani","sequence":"additional","affiliation":[{"name":"Laboratorio de Fagocitosis, Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"},{"name":"\u00c1rea de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A.","family":"Rabinovich","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunopatolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, C1428ADN Buenos Aires, Argentina;"},{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"e_1_3_3_1_2","unstructured":"; 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