{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:57:48Z","timestamp":1790632668984,"version":"4.1.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"24","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24592624"],"award-info":[{"award-number":["24592624"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,6,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Although central serous chorioretinopathy (CSC) presumptively shares pathophysiological basis with age-related macular degeneration (AMD), the\n                    <jats:italic>CFH<\/jats:italic>\n                    risk alleles for AMD are reportedly protective against CSC development. Our finding, that the\n                    <jats:italic>CFH<\/jats:italic>\n                    risk allele for AMD is protective against choroidal thickening in a Japanese cohort, indicates that\n                    <jats:italic>CFH<\/jats:italic>\n                    affects CSC development through its choroid-thickening effects rather than its association with AMD, highlighting the need for a new AMD classification, with CSC\/pachychoroid-associated choroidal neovascularization as a distinct disease. Furthermore, our genome-wide association study (GWAS) addressing choroidal thickness successfully discovered a susceptibility gene for CSC:\n                    <jats:italic>VIPR2<\/jats:italic>\n                    . Future GWASs on choroidal thickness will likely discover additional CSC susceptibility genes and provide key molecules to elucidate the pathophysiological difference between CSC and AMD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1802212115","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T11:38:08Z","timestamp":1527593888000},"page":"6261-6266","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":112,"title":["<i>CFH<\/i>\n                    and\n                    <i>VIPR2<\/i>\n                    as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy"],"prefix":"10.1073","volume":"115","author":[{"given":"Yoshikatsu","family":"Hosoda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 6068507 Kyoto, Japan;"},{"name":"Center for Genomic Medicine, 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