{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:40:47Z","timestamp":1792791647334,"version":"4.5.0"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"18","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"name":"Irma and Norman Braman Endowment","award":["Endowment fund"],"award-info":[{"award-number":["Endowment fund"]}],"id":[{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Suzi and Scott Lustgarten Center Endowment","award":["Endowment fund"],"award-info":[{"award-number":["Endowment fund"]}],"id":[{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Children's Hospital of Philadelphia Research Institute","award":["Institutional research fund"],"award-info":[{"award-number":["Institutional research fund"]}],"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Children's Discovery Institute of Washington University and St. Louis Children's Hospital","award":["MD-II-2013-269"],"award-info":[{"award-number":["MD-II-2013-269"]}],"id":[{"id":"https:\/\/ror.org\/00qw1qw03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH R01","award":["DK087715"],"award-info":[{"award-number":["DK087715"]}]},{"name":"NIH R01","award":["NS102272"],"award-info":[{"award-number":["NS102272"]}]},{"DOI":"10.13039\/100000912","name":"March of Dimes","doi-asserted-by":"crossref","award":["6-FY15-235"],"award-info":[{"award-number":["6-FY15-235"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Burroughs Wellcome Fund Clinical Scientist Award in Translational Research","award":["1008525"],"award-info":[{"award-number":["1008525"]}],"id":[{"id":"https:\/\/ror.org\/01d35cw23","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Neurons and muscularis macrophages (MM) interact closely in the adult bowel and enteric neurons modulate the inflammatory response of neighboring MM. Enteric neurons also produce the essential macrophage survival factor colony stimulating factor 1. How MM\u2013enteric neuron interactions are established during development has not been previously investigated. Surprisingly, we find that MM colonize fetal mouse bowel before enteric neurons. Furthermore, neonatal mouse and human bowel that is missing enteric neurons contains normal numbers of well-patterned, phenotypically intact MM. These data suggest that enteric neurons are not required for bowel colonization by MM and that modulatory neuro-immune circuits of the bowel mature postnatally and may be influenced by environmental factors like intestinal microbes or diet.<\/jats:p>","DOI":"10.1073\/pnas.1802490115","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:52:22Z","timestamp":1523965942000},"page":"4696-4701","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":85,"title":["Muscularis macrophage development in the absence of an enteric nervous system"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9836-5005","authenticated-orcid":false,"given":"Marina","family":"Avetisyan","sequence":"first","affiliation":[{"name":"Abramson Research Center, The Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104-4318;"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Rood","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Abramson Research Center, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104-4318;"},{"name":"Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Huerta Lopez","sequence":"additional","affiliation":[{"name":"Abramson Research Center, The Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104-4318;"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarshi","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Abramson Research Center, The Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104-4318;"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Wright-Jin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Dougherty","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Behrens","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Abramson Research Center, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104-4318;"},{"name":"Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-1765","authenticated-orcid":false,"given":"Robert O.","family":"Heuckeroth","sequence":"additional","affiliation":[{"name":"Abramson Research Center, The Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104-4318;"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.023"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2012.02.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21444"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:HIJO.0000039840.86420.b7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.050"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304676"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","unstructured":"HB Mikkelsen L Thuneberg Op \/ op mice defective in production of functional colony-stimulating factor-1 lack macrophages in muscularis externa of the small intestine. 295 485\u2013493 (1999).","DOI":"10.1007\/s004410051254"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-016-3862-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.149"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3353-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/367380a0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00806.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23423"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69781"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.09.023"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01025.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12418"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091611"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/40146"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.08.040"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5267-14.2015"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.11.004"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3053-11.2011"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.060053"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.02.013"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087785"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3390"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150414"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.014"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.20.3963"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619406114"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00092.2010"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.225938"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.214056"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.03.017"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01105.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059066"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24660"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18644"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22302"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.028"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1802490115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1802490115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T04:04:05Z","timestamp":1649822645000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1802490115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":42,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1073\/pnas.1802490115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1802490115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}