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U.S.A."],"published-print":{"date-parts":[[2018,4,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The lamin proteins are an important component of the nuclear scaffold. Abnormal lamins can cause a variety of disorders called laminopathies, one of which is the premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS). Cells from HGPS patients show improvement when treated with rapamycin and everolimus. These drugs stimulate the cellular system that disposes of abnormal proteins. Several other laminopathies also produce abnormal lamin proteins, so we hypothesized that everolimus would also be beneficial. We treated cells from six different laminopathy patients with everolimus and saw improved nuclear shape in most cells. Treatment also increased the cells\u2019 ability to multiply and delayed senescence. These results suggest that everolimus might have clinical benefit for multiple laminopathy syndromes.<\/jats:p>","DOI":"10.1073\/pnas.1802811115","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T15:17:08Z","timestamp":1522077428000},"page":"4206-4211","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts"],"prefix":"10.1073","volume":"115","author":[{"given":"Amanda J.","family":"DuBose","sequence":"first","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 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