{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:29:03Z","timestamp":1791091743607,"version":"4.1.0"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,9,12]]},"abstract":"<jats:p>We present a theoretical framework that enables us to dissect out\n the parametric dependencies of the pathogenesis of prion diseases. We\n are able to determine the influence of both host-dependent factors\n (connectivity, cell density, protein synthesis rate, and cell death)\n and strain-dependent factors (cell tropism, virulence, and replication\n rate). We use a model based on a linked system of differential\n equations on a lattice to explore how the regional distribution of\n central nervous system pathology in Creutzfeldt-Jakob disease,\n Gerstmann-Str\u00e4ussler-Scheinker syndrome, and fatal familial\n insomnia relates to each of these factors. The model then is used to\n make qualitative predictions about the pathology for two possible\n hypothetical triggers of neuronal loss in prion diseases. Pathological\n progression in overexpressing mouse models has been shown to depend on\n the site of initial infection. The model allows us to compare the\n pathologies resulting from different inoculation routes.<\/jats:p>","DOI":"10.1073\/pnas.180317097","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"10573-10577","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":22,"title":["Mapping the parameters of prion-induced neuropathology"],"prefix":"10.1073","volume":"97","author":[{"given":"Michael P. H.","family":"Stumpf","sequence":"first","affiliation":[{"name":"The Wellcome Trust Centre for the Epidemiology of Infectious\r Disease, Department of Zoology, South Parks Road, Oxford OX1 3PS,\r United Kingdom; and Institute for Advanced Study,\r Princeton, NJ 08540"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Krakauer","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Centre for the Epidemiology of Infectious\r Disease, Department of Zoology, South Parks Road, Oxford OX1 3PS,\r United Kingdom; and Institute for Advanced Study,\r Princeton, NJ 08540"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,8,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801762"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/39758"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072645"},{"key":"e_1_3_4_4_2","first-page":"57","volume-title":"Prion Diseases","author":"Ironside J","year":"1997","unstructured":"J Ironside, J Bell Prion Diseases, eds J Collinge, M Palmer (Oxford Univ. 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