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In this study, we showed that the selective ER\u03b2 agonist LY500307 could potently suppress lung metastasis of cancer by recruitment of antitumor neutrophils to the metastatic niche. These chemotactic effects of LY500307 for neutrophils were primarily mediated by ER\u03b2 activation-induced IL-1\u03b2 release by the tumor cells. Our study provides the rationale that pharmacological activation of ER\u03b2 could augment innate immunity to suppress cancer metastatic colonization to lung, implicating the potential use of selective ER\u03b2 agonists for the treatment of cancer patients with metastasis.<\/jats:p>","DOI":"10.1073\/pnas.1803291115","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T14:20:22Z","timestamp":1522246822000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":69,"title":["Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis"],"prefix":"10.1073","volume":"115","author":[{"given":"Linjie","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education and State Key Laboratory of Biotherapy, West China Second University 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