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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,8,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mycobacteria as well as other bacteria remodel their ribosomes in response to zinc depletion by replacing zinc-binding ribosomal proteins with zinc-free paralogues, releasing zinc for other metabolic processes. In this study, we show that the remodeled ribosome acquires a structurally stable but functionally inactive and aminoglycoside-resistant state in zinc-starved\n                    <jats:italic>Mycobacterium smegmatis<\/jats:italic>\n                    . Conversely,\n                    <jats:italic>M. smegmatis<\/jats:italic>\n                    cells that are growth arrested in zinc-rich conditions have unstable ribosomes and reduced survival. We further provide evidence for ribosome remodeling in\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    in host tissues, suggesting that ribosome hibernation occurs during TB infections. Our findings could offer insights into mechanisms of persistence and antibiotic tolerance of mycobacterial infections.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1804555115","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T15:16:36Z","timestamp":1532358996000},"page":"8191-8196","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":96,"title":["Zinc depletion induces ribosome hibernation in mycobacteria"],"prefix":"10.1073","volume":"115","author":[{"given":"Yunlong","family":"Li","sequence":"first","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjuli R.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Koripella","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem S.","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishan","family":"Lin","sequence":"additional","affiliation":[{"name":"Proteomics\/Mass Spectrometry Facility, Center for Functional Genomics, University at Albany, Rensselaer, NY 12144;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Wade","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;"},{"name":"Department of Biomedical Sciences, University at Albany, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0931-5503","authenticated-orcid":false,"given":"Todd A.","family":"Gray","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;"},{"name":"Department of Biomedical Sciences, University at Albany, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3404-8312","authenticated-orcid":false,"given":"Keith M.","family":"Derbyshire","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;"},{"name":"Department of Biomedical Sciences, University at Albany, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201;"},{"name":"Department of Biomedical Sciences, University at Albany, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-2643","authenticated-orcid":false,"given":"Anil K.","family":"Ojha","sequence":"additional","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;"},{"name":"Department of Biomedical Sciences, University at Albany, Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"e36972","DOI":"10.1371\/journal.pone.0036972","article-title":"Phylogenomics of prokaryotic ribosomal proteins","volume":"7","author":"Yutin N","year":"2012","unstructured":"N Yutin, P Puigb\u00f2, EV Koonin, YI Wolf, Phylogenomics of prokaryotic ribosomal proteins. 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